What causes heart disease?

A few weeks back I wrote an article about the drug class known as “PCSK9 inhibitors”, and how they seem to lower the risk of a heart attack, and how there is even preliminary evidence to support the notion that they prolong life. The article wasn’t particularly popular among some readers of this blog, presumably because it was construed as supporting the LDL hypothesis … Read more

Do PCSK9 inhibitors prolong life?

In light of the recent decision by the UK health authorities to approve inclisiran for use in patients, I thought it would be interesting to delve in to how good the class of drugs it belongs to, the PCSK9 inhibitors, really are. PCSK9 inhibitors can be thought of as “next generations statins”. Like statins, they work under the assumption that the lipid transport molecule LDL … Read more