I’ve been thinking about starting a podcast of my own for a while now, where I talk to the most interesting and original thinkers in health and medicine. I listen to a lot of medical and health science podcasts, and there are some that are truly excellent, such as The Drive with Peter Attia, Ivor Cummins’ Fat Emperor podcast, and the Diet Doctor podcast with … Read more
Do PCSK9 inhibitors prolong life?
In light of the recent decision by the UK health authorities to approve inclisiran for use in patients, I thought it would be interesting to delve in to how good the class of drugs it belongs to, the PCSK9 inhibitors, really are. PCSK9 inhibitors can be thought of as “next generations statins”. Like statins, they work under the assumption that the lipid transport molecule LDL … Read more
Is the cholesterol hypothesis dead?
Is there any life left in the cholesterol hypothesis (a.k.a. the lipid hypothesis)? Is there anything left for serious scientists to cling to or is time for its mouldering corpse to end up on the trash heap of medical history, alongside lobotomy, bloodletting and the theory of the four humors? I was asked this question by a reader of this blog recently, and as it … Read more