Do PCSK9 inhibitors prolong life?

In light of the recent decision by the UK health authorities to approve inclisiran for use in patients, I thought it would be interesting to delve in to how good the class of drugs it belongs to, the PCSK9 inhibitors, really are. PCSK9 inhibitors can be thought of as “next generations statins”. Like statins, they work under the assumption that the lipid transport molecule LDL … Read more

Ketogenic diet safe and healthy?

The ketogenic diet (in earlier iterations known as the Atkins diet and the Low Carb High Fat diet) has been vilified for decades by members of the nutrition establishment, because it is pretty much telling people to do the exact opposite of what the establishment is telling them to do. While official diet guidelines recommend cutting down on fat intake, the ketogenic diet instead recommends … Read more

Will the mediterranean diet make you live longer?

The so-called mediterranean diet is perhaps the best publicized “healthy diet”, and has been for decades. It was “discovered” by Ancel Keys back in the 1970’s, and is based on the diets that were typical in the mediterranean region during the 60’s and 70’s.

Ancel Keys is largely responsible for the current slate of official diet recommendations promulgated by health authorities around the world, most … Read more

Is the cholesterol hypothesis dead?

Is there any life left in the cholesterol hypothesis (a.k.a. the lipid hypothesis)? Is there anything left for serious scientists to cling to or is time for its mouldering corpse to end up on the trash heap of medical history, alongside lobotomy, bloodletting and the theory of the four humors? I was asked this question by a reader of this blog recently, and as it … Read more