Is curcumin effective for knee pain?

Two randomized controlled trials have been published in the recent past, one last year, and the other just a few months back, that look at the effectiveness of curcumin as a treatment for knee pain, and more specifically for knee pain induced by osteoarthritis. read more

How much do statins prolong life?

One problem with all the trials of statins is that they look at the probability of still being alive after x years. But that’s not really the question patients want answered. Patients want to know how much longer they can expect to live if they take a statin every day for the rest of their lives. Is it weeks? months? years? decades? read more

Deprescribing: the most important health intervention you’ve never heard of?

Last year I spent a couple of months working as a physician in a geriatric hospital, i.e. a hospital that specializes in taking care of elderly people. One thing that struck me particularly was the large number of medications each patient was on. I don’t think it would be much of an exaggeration to say that the average patient had ten or more medications that they were taking on a daily basis. read more

Is the cholesterol hypothesis dead?

Is there any life left in the cholesterol hypothesis (a.k.a. the lipid hypothesis)? Is there anything left for serious scientists to cling to or is time for its mouldering corpse to end up on the trash heap of medical history, alongside lobotomy, bloodletting and the theory of the four humors? I was asked this question by a reader of this blog recently, and as it happens, a systematic review was recently published in Evidence Based Medicine (my favorite medical journal, mainly because it is edited by the brilliant Dr. Carl Heneghan) that definitively answers this question, so I thought it would be interesting to go through what the evidence says together. read more

Does hydroxychloroquine have a role in treating covid-19?

Several people have contacted me over the last few weeks asking for my opinions on hydroxychloroquine. I’ve invariably answered that I don’t know, since I haven’t looked at the data myself. I felt that it was time to rectify that situation. read more

Should you take fever lowering drugs when you’re sick?

Most of us probably take fever lowering drugs, like paracetamol (a.k.a. acetaminophen, tylenol, panadol, alvedon), aspirin, or ibuprofen (a.k.a. advil, motrin, ipren), when we get a high temperature. The technical term for these drugs is antipyretics. After half an hour or so, we start to feel better and maybe don’t have to spend the whole day in bed. But it is well understood among researchers studying the immune system that the fever is in itself an important part of the body’s defence against infection. Our immune system works better at a higher temperature, and many pathogens have trouble replicating at a higher temperature. So, does taking antipyretics increase the risk of a more severe infection, or even of dying? And does it delay recovery? read more