Three separate covid vaccine trials have now had their results published in peer-reviewed journals (Astra-Zeneca, Pfizer, and Moderna), and the vaccines have already been approved for use in multiple countries. In light of that, I think it’s time to look in to how effective and safe the vaccines are, especially considering that many of us are about to be given the option to take them (and some of us already have).
First out of the gate was the Astra Zeneca vaccine, for which trial data was published in The Lancet on the 8th of December. All vaccines have the same underlying principle – to activate a person’s immune system so that it develops immune memory to a specific disease, without actually causing the person to have the disease you want to protect against. But there are multiple ways in which that goal can be achieved. The Astra Zeneca vaccine is a so called “adenoviral vector” vaccine.
In order to understand how this vaccine works, you first need to understand how a virus works. In general, a virus consists of two main parts, a shell made of protein, and inside the shell, a string of nucleotides that make up the viral genome (which can be DNA or RNA depending on the type of virus). The shell latches on to a target cell that it’s going to infect, and then it injects the genome in to the cell. The target cell has a hard time telling the difference between the virus’s genome and its own DNA or RNA, so it treats the viral genome like its own, and starts using it as a blueprint to produce new viruses.
Luckily our ancestors have been dealing with viruses for hundreds of millions of years, so our bodies have some tricks up their sleeves to deal with them. One of those tricks is to take proteins that are being produced inside the cell, and present them on the surface of the cell. This allows the immune system to detect unusual proteins that aren’t normally produced by the body, and to mount an immune response.
The adenovirus vector vaccine uses this as the basis for creating immunity to covid. Adenoviruses are common, and frequently cause disease in humans. In an adenovirus vector vaccine however, one of the viral genes has been deleted, which means that the virus can infect a cell, but it can’t get the cell to start producing new copies of itself. Thus, it can’t generate a real infection. While removing a gene, another gene is also added – a gene that is normally produced by the virus that you want to create immunity against. In the case of the Astra-Zeneca vaccine, the gene that has been added codes for the SARS-CoV-2 spike protein, which is the part of the virus that attaches to the target cell.
What happens when you inject the vaccine in to a person is that the adenovirus infects cells, and injects its genome in to them. Those cells then start producing the proteins that the viral genome codes for, including the specific protein that you want the immune system to react to. These proteins then get expressed on the surface of the infected cells, and this results in activation of the immune system, and hopefully long term immunity.
Ok, now we know how the Astra-Zeneca vaccine is supposed to work (this is also how the Russian Sputnik vaccine is supposed to work, but I’m not discussing that vaccine in this article because no phase three trial data have yet been published in a peer-reviewed journal). Let’s get in to the details of the trial.
This was a randomized controlled trial, split in to three separate arms, a British arm, a Brazilian arm, and a South African arm. The work was financed by Astra-Zeneca, the Bill and Melinda Gates foundation, the British government, and a couple of other private and public organizations.
The three arms varied somewhat in terms of the methodology used. The British and Brazilian arms were single-blind, while the South African arm was double-blind. In other words, in both the British and the Brazilian arm, the researchers knew who was in the vaccine group and who was in the control group. This is strange, and really quite unforgivable, because it makes it much easier for the researchers to manipulate the results in lots of little ways when they know who is in which group. There is no reason why a big, well-financed study like this shouldn’t use a double-blind methodology across all trial arms.
A second oddity about the study is that the control group in both the British and Brazilian arm wasn’t getting a placebo. It was getting another vaccine, for meningococcus. The South African arm however did get a proper placebo consisting of saline (salt water). The researchers motivate the use of another vaccine in the control group by saying that it decreases the risk of the participants being “unblinded”, in other words that they will realize whether they are in the vaccine group or in the control group. This is true to an extent. If you develop a fever shortly after getting the vaccine, you’ll probably deduce that you’ve been given a real vaccine, not a placebo. But many people don’t develop a fever after getting a vaccine, so not getting a fever isn’t going to tell you that you’re in the placebo group. Therefore I really don’t see why the researchers were so concerned about unblinding of participants, especially considering that they didn’t bother to blind themselves to the group allocation.
The main problem with not giving the control group a placebo is that it makes it harder to determine the extent to which the vaccine causes side effects, and it will tend to make the vaccine look more harmless than it is. Overall, the South African arm is therefore the one with the soundest methodology, since it is the only arm that is double-blind, and also the only arm that has given the control group a placebo rather than an active drug. Unfortunately, the South African arm had barely accrued any cases when the researchers decided to push ahead with getting their results published, so the published data actually only includes results from the UK and Brazilian arms.
All three arms gave two doses of the vaccine, although the amount of vaccine in the doses varied somewhat, and the time that was allowed to pass between the first and second dose also varied somewhat (it is common with vaccines to give one dose first, and then give a second “booster” dose a few weeks or months later, since this has been shown to increase the probability of developing long lasting immunity).
The published data include results from 12,000 participants (half from the UK, and half from Brazil), and the total amount of follow-up after receiving two doses is 29,000 months, so an average of 2,4 months of follow-up per participant (if you instead go by when participants received their first dose, the average follow-up period is 6,4 months). Of the 12,000 participants, 87% were aged 18-55. None were aged below 18. 8% were between 56 and 70, and only 4% were over 70. This is a problem. Even though we know that people under 70 years of age are at very low risk of severe disease, and the only real reason to even bother making a vaccine is that there is some risk to people over 70, this group made up only a tiny portion of the total population being studied.
This is in my opinion the biggest weakness of the study, bigger than not blinding the researchers, and bigger than using another vaccine for the control group instead of a placebo. It is well known that older people are less likely to respond favorably to vaccines than younger people, because they have less well functioning immune systems. In other words, the probability that an 80 year old is going to develop immunity after a vaccine is often much lower than the probability that a 40 year old is going to develop immunity. And yet this study was done almost entirely in young people below the age of 55.
This study is not even close to being powered to answer the question of whether people over 70 will develop effective immunity after taking the vaccine. As you probably noticed, children were also excluded from the study, so the study doesn’t tell us anything about what effect the vaccine might have on children either, or whether it’s safe for them.
Additionally, the average BMI (Body Mass Index) of the participants was pretty ideal, around 25, which is pretty much the healthiest BMI you can have. Again, this is a problem, because the people most at risk from covid are the seriously obese, and this study tells us nothing about whether the vaccine works for them. Just as with older people, people who are obese have less well functioning immune systems, and are probably less likely to develop immunity after receiving a vaccine.
Participants in the study were in general pretty healthy in other ways too. Only 11% had underlying cardiovascular disease. Only 12% had underlying respiratory disease. And only 2% had diabetes. So, even before we get to the results, we know one thing – this study cannot tell us anything about the ability of the vaccine to protect the people who are most at risk of severe disease. And it cannot tell us whether the vaccine is safe for these people either.
As mentioned earlier, follow-up was on average only 2,4 months per participant. This should be enough to catch most side-effects, since vaccine side-effects tend to develop within the first days and weeks after injection, but it is still very much on the short side. It means for example that a side-effect that develops three months after getting the shot won’t detected in the study. Apart from that, the results that were published on December 8th only included 12,000 people, which is quite small for a vaccine trial. It means that the study is likely to detect common side and even quite uncommon side effects, but rare side effects that only affect say 1 in 10,000 people, won’t be detected.
Rare side-effects don’t matter so much for normal drugs that are used to relieve symptoms of existing diseases. But they do matter with vaccines, because you’re essentially giving a healthy person something that they don’t need, in order to slightly lessen their risk of catching a disease at some point in the future. Because the benefit from a vaccine to an individual is generally much smaller than for drugs that are used for treatment of existing conditions, the side effects that are considered acceptable also have to be much less common.
The primary endpoint for the trial was PCR confirmed symptomatic covid-19. If participants developed symptoms that could be suggestive of covid, they were supposed to get in touch with the organizers of the trial, and they would then be tested for covid with a PCR test.
I think this endpoint is problematic, because to me the important thing isn’t whether the vaccine prevents young people getting a cold, it’s whether it prevents frail elderly people dying. And the design chosen makes that question impossible to answer. If it had been up to me, the trial would only have included people over 70 years of age with underlying co-morbidities, and the primary end point would have been death, a nice hard end point with little scope for manipulation. Unfortunately Astra-Zeneca never asked me for my opinions on the subject, so now this very flawed and limited study is what we have. Anyway, let’s get to the results.
Among the participants who got the vaccine, 0,5% developed symptomatic covid over the course of follow-up. Among the control group, 1,7% developed symptomatic covid. This is a 70% relative risk reduction in favor of the vaccine, and it is statistically significant. This is actually a pretty good result, for what it is. If you’re a young, otherwise relatively healthy adult, then the vaccine reduces the probability that you will develop symptomatic covid by around two thirds.
Having said that, we don’t really care about preventing colds (at least I don’t). What matters is preventing severe disease requiring hospitalization, and death. This study was too small to have any chance of seeing a significant effect on deaths in such an otherwise healthy group of participants, but not too small to see an effect on hospitalizations.
It generally takes a few weeks after receiving the vaccine until robust immune memory has developed, so it makes sense to start looking for an effect on hospitalizations a few weeks after immunization. From three weeks after receiving the first dose of vaccine, there were 10 hospitalizations for covid in the control group and zero in the vaccine group.
That is impressive. To me, it’s far more impressive than the 70% reduction in symptomatic covid, because it’s the reduction in severe disease that really matters.
Of course, it’s not just the effectiveness of the vaccine that matters. We also want to know that it is likely to be safe. So let’s look at the safety data. Overall, 0,7% of individuals in the vaccine arm had a serious adverse event after at least one dose of vaccine, compared with 0,8% in the control arm. Of course, the control arm wasn’t receiving a placebo, it was getting a meningococcal vaccine, so it’s actually impossible to say what the risks of the vaccine are in relation to placebo. All we can say is that the covid vaccine overall doesn’t appear to cause more adverse events than the meningococcal vaccine.
In total, there were 79 serious adverse events in the group getting the vaccine, and those adverse events are evenly spread out among lots of different types of event, the vast majority of which could not possibly have anything to do with the vaccine.
The only really worrying thing is that two people in the covid vaccine group developed transverse myelitis a few weeks after getting the vaccine, an extremely rare and serious neurological condition that normally affects about one in 200,000 people per year. One of those people had an underlying undiagnosed multiple sclerosis, a condition which strongly predisposes to development of transverse myelitis, but that doesn’t mean that it wasn’t the vaccine that triggered the myelitis.
So, it is possible that the covid vaccine causes transverse myelitis in a small proportion of those vaccinated. At present it seems like the the risk of developing transverse myelitis after getting the vaccine is about one in 3,000, but it could be much higher or much lower. We won’t know until many more people have received the vaccine.
Would I take this vaccine personally? No, because I’m young and healthy and I therefore estimate that the risk of me getting severe covid is infinitesimal, and I’m not convinced that the benefits outweigh the potential harms, considering the possible risk of transverse myelitis. If there wasn’t that possible signal of harm, then I’d probably be willing to take the Astra-Zeneca covid vaccine.
On balance, the benefits probably outweigh the harms for older adults, who are at greater risk of severe disease. I say that even though they were not really included in this study to any great extent. Even if the vaccine is less effective in older adults than in younger adults, which it probably is, this group is also at much higher risk of severe disease, so the risk/benefit ratio probably favors getting the vaccine.
Would I let my children have it? No way. Not until there are studies showing that it’s safe and effective in children. It’s only little over a decade since an influenza vaccine (pandemrix) was rushed through and given to children based on limited evidence, causing hundreds in Europe to develop narcolepsy, a debilitating lifelong disease.
There is one final thing about the Lancet article that is odd, and that is that the exclusion criteria are not listed anywhere in the text. Normally inclusion and exclusion criteria are listed clearly in the method section, but as far as I can tell, they’re not there. This is very strange. It’s possible that they’re buried somewhere in the book length appendix, but I wasn’t personally able to find them there either. We know that children were excluded from the data, but we don’t know if there were any other groups that were intentionally excluded. Were people with previous allergic drug reactions excluded? Were people with autoimmune diseases excluded? What about pregnant women? Until this is clarified, people who belong to these groups should think twice about taking the vaccine.
Let’s move on, and look at the next vaccine. Two days after the Astra Zeneca vaccine data was published in The Lancet, the Pfizer vaccine data was published in the New England Journal of Medicine. The Pfizer vaccine is an mRNA vaccine (as is the Moderna vaccine, which we’re going to discuss after we’ve finished going through the data on the Pfizer vaccine). This is a new vaccine technology, that hasn’t been used previously. Fundamentally though, the technology isn’t that different in practice from the previously described adenoviral vector vaccine. The mRNA vaccine consists of two parts – a sequence of RNA nucleotides that code for a specific protein, and an outer “shell” that is in this case made of lipids, known as a lipid nanoparticle.
After being injected in to the body, the lipid nanoparticles are taken up by cells through a process known as endocytosis (a standard method through which cells take things up from the outside environment). The RNA sequence is then released inside the cell. Just as with the viral vector vaccine, the cell is unable to tell the difference between this imported RNA and its own RNA, so it uses it as a blueprint and produces proteins based on it. These proteins are then presented on the cell surface, and this results in activation of the immune system, which recognizes them as foreign. As with the Astra-Zeneca vaccine, the Pfizer vaccine and the Moderna vaccine cause the body’s cells to start producing the SARS-CoV-2 spike protein.
Ok, now we understand how the mRNA vaccine works. Let’s get in to the details of the Pfizer study. This was a randomized controlled trial with a total of 44,000 participants, in which 22,000 people received two doses of the Pfizer covid vaccine and 22,000 people received an inert placebo. Just from this, two things are obvious. First, the results from Pfizer involve many more people than those discussed above from Astra-Zeneca. And second, Pfizer have actually given the control group a placebo (consisting of saline) instead of another vaccine. Just those two things make me like this study a lot more before knowing anything else about it.
In order to be included in the study you had to be at least 16 years old and you had to be fundamentally healthy. Chronic health conditions were ok if they were deemed to “stable”. You were excluded from the study if you were receiving immunosuppressive therapy or if you had an immune compromised state for any other reason, if you had ever had a severe allergic reaction to a vaccine, if you were pregnant or breastfeeding, or if you had an auto-immune disease.
So this study says nothing about whether the vaccine is safe and effective for children. It doesn’t say anything about whether the vaccine is effective or safe for pregnant women and breastfeeding women. It doesn’t say anything about whether the vaccine is safe and effective for people with weakened immune systems.
The study doesn’t say anything about whether the vaccine is safe and effective for people with auto-immune diseases. This is a problem, as we’ve already seen with the Astra Zeneca vaccine and the participant with undiagnosed MS who developed transverse myelitis less than two weeks after receiving the vaccine. People with known auto-immune diseases are more likely to develop auto-immune complications after taking a vaccine.
And the study doesn’t say anything about whether the vaccine is safe and effective for people who tend to have strong allergic reactions. In fact we now know it isn’t safe for this group, since a couple of people in the UK did develop anaphylaxis after getting the Pfizer vaccine. If this group had been included in the study, the problem would have been discovered before the vaccine started being rolled out to large numbers of people outside of studies.
So, there’s a pretty extensive group of people we know, even before getting in to the results, that this study cannot provide useful information for. In fact, the list of people excluded is so extensive that I wouldn’t be surprised if more than half of all the people on the planet would be excluded for one reason or another. If you belong to one of these groups, then this study cannot tell you whether the vaccine is safe and effective for you.
Apart from the long list of exclusion criteria, it is of course a problem that people needed to be fundamentally healthy to be included in the study. As we’ve already discussed, the people who get really sick and risk dying of covid are not fundamentally healthy. The average person who dies of covid has three known underlying conditions. And those are the people we need the vaccine to be safe and effective for. Unfortunately, the design of this trial, just like with the Astra-Zeneca vaccine trial, makes is very hard to answer that question.
The primary end point of the study was, similarly to the Astra-Zeneca trial, reduction in symptomatic covid-19, defined as a positive PCR test and at least one symptom suggestive of the disease. As mentioned before, 22,000 people were recruited in to each group, so there were 44,000 people in total. That’s a pretty good number, and should be enough to detect all but the most uncommon side effects. The participants were recruited at a number of different sites around the world (USA, Argentina, Brazil, South Africa, Germany, Turkey).
The median follow-up period after the second shot was only two months, which is short, but should be enough to catch the vast majority of side effects. The two cases of transverse myelitis that occurred with the Astra-Zeneca vaccine both happened within two weeks of vaccination, and as far as I am aware pretty much every single case of narcolepsy occurring after the Pandemrix vaccine disaster also happened within a few weeks.
35% of participants were obese, which is excellent, since this is a group that is at risk of severe disease, and we want to know if the vaccine protects them. Less good is that the study had a very small proportion of elderly people. As with the Astra-Zeneca study, less than 5% of participants were 75 years or older.
Ok, let’s get to the results. Among those getting the placebo, 0,9% developed symptomatic covid. Among those getting the vaccine, 0,05% developed symptomatic covid. That is a 95% relative risk reduction and it is highly statistically significant. That is an impressive result, much better than I ever would have thought would be possible in such a short space of time.
The result appears at first sight to hold up even for the people aged 75 years and older, with 5 cases among those getting placebo and zero cases among those getting the vaccine. Unfortunately, due to the small size of that group, the result is not statistically significant, so we can’t actually say based on this study that the vaccine protects people aged 75 and older.
With that said, the vaccine does seem to protect most people against infection. However, just as with the Astra-Zeneca vaccine, we don’t care about whether the vaccine decreases the number of people experiencing a cold, we want to know whether the vaccine protects against severe disease. After having gotten at lest one dose of the vaccine, one person in the vaccine group developed severe covid, while nine people in the placebo group developed severe covid. The reduction in relative risk after getting at least one dose of vaccine is 89%, which is again very impressive. So the Pfizer vaccine does seem to protect against severe covid, just like the Astra-Zeneca vaccine does.
But is it safe?
Overall there were 240 events in the vaccine group that were classified as severe, compared with 139 in the placebo group. That is concerning. Severe adverse events were 73% more common in the vaccine group than in the placebo group. The vaccine should ideally decrease severe adverse events (by decreasing the number of people experiencing severe covid). It certainly shouldn’t increase them. Unfortunately Pfizer aren’t kind enough to provide a breakdown of what the adverse events were, so it’s impossible for us to figure out whether the drastic increase in severe adverse events after vaccination is something we need to be concerned about, and whether it should cause us to avoid the vaccine.
Note that, when it comes to adverse events, severe and serious are not the same thing. A severe adverse event is something that causes a lot of symptoms, but not necessarily something that is serious in terms of its consequences for the patient. A serious adverse event is, on the other hand, well, serious.
If we instead look at serious adverse events, the difference is much smaller. 0,6% developed a serious adverse event in the vaccine group, compared with 0,5% in the placebo group. However, it’s not great that there were more serious adverse events in the vaccine group. If anything, that number should be lower in the vaccinated group, not higher. And again, Pfizer are not telling us what those adverse events were.
Would I personally be willing to take the Pfizer vaccine? No, not until Pfizer publishes a detailed breakdown of what the adverse events were, so I can tell if there’s something in there that I should be worried about or not. If Astra-Zeneca hadn’t provided a breakdown of adverse events, it would have been impossible to see that there is a signal that their vaccine might cause a seriously increased risk of transverse myelitis.
Having said that, the proportion of people experiencing a severe or life threatening adverse event in the vaccine group was only 1,2%, so 98,8% didn’t experience one. If you are over 70 years old or otherwise belong to a risk group, it’s likely worth taking the vaccine even without having the adverse event information, just due to the fact that the vaccine is clearly highly effective against covid, and so the benefit/risk calculation becomes quite different than it is for someone who is young and healthy.
Let’s move on to the final trial, of the Moderna vaccine. I’m going to run through this one a little bit more quickly, because in many respects it is similar to the previous two trials. The results were published in The New England Journal of Medicine at the end of December. The technology used for this vaccine is identical to the technology used for the Pfizer vaccine, so it’s reasonable to expect that the results would be similar. This was a randomized controlled trial involving 30,000 participants, who were recruited from a large number of sites across the United States. The study was primarily funded by the US government and by Moderna. Half the participants received two doses of the Moderna covid vaccine one month apart, and half received two doses of a placebo injection (consisting of saline). The median length of follow-up after receiving the second dose was two months.
As with the previous two trials, the primary objective of the study was to see if there was a reduction in cases of covid-19, which in this study was defined as at least two symptoms suggestive of covid-19 plus a positive covid PCR test.
The study included adults over the age of 18. As with the previous studies, participants had to be healthy or “stable” in terms of any underlying chronic conditions. The study excluded pregnant and breastfeeding women, people with allergies, and people who were immunosuppressed. The average BMI was 29. Only 5% of participants were over the age of 75, so as with the other two studies the proportion of participants in the oldest category was low. 5% had chronic lung disease. 5% had significant cardiac disease. 7% were obese. And 10% had diabetes.
Ok, so what were the results?
Among those who had received the placebo injections, 1,3% developed covid. Among those who had received the vaccine, 0,07% developed covid. That represents a 94% reduction in cases, and it is highly statistically significant. If we look at those over 65 (average age 70), then we see an 86% reduction in cases, so the vaccine seems to be highly effective even for older people (although unfortunately no data is provided for the very oldest people, aged 80+).
The results are even more impressive if we look only at people with severe covid. Among those getting the placebo, there were 30 cases. Among those getting the vaccine, not a single person developed a severe case of covid. So, just as with the previous two vaccines, the Moderna vaccine appears to be highly effective against covid-19.
What about safety?
1,0% of participants in the placebo group experienced a serious adverse event and 1,0% of participants in the vaccine group experienced a serious adverse event. Ideally we would like to see fewer serious adverse events in the vaccine group, but there weren’t enough cases of severe covid-19 for the vaccine to have any noticeable positive effect on the overall number.
If we look through the list of serious adverse events (yes, unlike Pfizer, Moderna actually provided this information), we see that there is nothing that could reasonably be thought to have been caused by the vaccine (unlike the transverse myelitis seen in the Astra-Zeneca study), and there is nothing that sticks out as being more common in the vaccine group than in the placebo group.
Overall, the Moderna vaccine does appear to be both effective and safe. Would I be willing to take it? Yes, I would, actually. There is a strong signal of benefit, and zero signal of harm. Considering that there were 15,000 people in the vaccine group, any serious side effects that can happen as a result of the vaccine are likely to be very rare (in those groups that were included in the study).
Ok, let’s wrap up. So all three vaccines appear to be highly effective at preventing covid-19, although both the Pfizer vaccine and the Moderna vaccine are clearly more effective than the Astra-Zeneca vaccine. In terms of safety, I have significant concerns about the Astra-Zeneca vaccine, considering that there is a signal suggesting that it increases your risk of developing transverse myelitis by a hundredfold or more. Future research will have to show whether that is a real risk or not. I also have concerns about the Pfizer vaccine, since there was a 73% increase in severe adverse events among those taking the vaccine, an issue that Pfizer hasn’t bothered to address at all, and I am also concerned about the fact that Pfizer does not provide a detailed breakdown of adverse events, which makes it impossible to see if there is anything in there that we should be worried about. The Moderna vaccine does appear to be safe however, based on the data available up to now.
One final point. None of these studies tell us whether the vaccines are safe and effective for children. It would be unethical to start vaccinating children without first having made sure that it’s safe, especially considering that the risk to children from covid is infinitesimal. The same applies to pregnant and breastfeeding women, people with immune disorders, and people with severe allergies. If you belong to one of these groups, you should probably think extra long and hard before getting vaccinated, because these groups were not represented in the studies, and it is therefore not clear that the benefits outweigh the harms.
323 thoughts on “Are the covid vaccines safe and effective?”
Dear Sebastian. Thanks a lot for this detailed and careful analysis. In Iceland around 4,000 people in nursing homes have been vaccinated now. Four subsequent deaths were reported and I think yesterday there was one more. It is stated that it is not known if those deaths are related with the vaccine, but at least there must be some suspicion since they were reported. Now I wonder, is there a reason to believe old and frail people are in danger from the Pfizer vaccine? How is this in other countries?
Yes! That is my question too! Is there a scientifically determined percentage of incidents that are required to define a cluster? Also, how do we define long term efficacy? At what vanishing point will cluster incidents be determined as coincidence rather than causation? Thus far it seems negative reactions are explained away. “Oh you had to have had some Covid in your system to cause this”, as example. If this is the case, why aren’t we administering rapid result tests before vaccinating?!
Elderly dying soon after receiving the vaccine are explained away as old and dying anyway.
Distribution seems spotted, varied and the very antithesis of scientific method. This all seems literally and figuratively taking a shot with one’s health. General public are perhaps so fatigued by political and Covid induced restrictions, they will risk anything for a return to normalcy. The vaccine seems not our messiah. A vaccine that isn’t. It is all a bit much to absorb.
Thanks. The article is very useful in determing whether or not I will take the vaccine assuming that taking it is not mandatory.
The fundamental question is whether there should be vaccine products for SARS-CoV-2 at all? These vaccines are called ‘COVID-19’ vaccines, but is this the correct terminology considering that the virus may not cause serious disease in most instances?
As you say Sebastian “Luckily our ancestors have been dealing with viruses for hundreds of millions of years, so our bodies have some tricks up their sleeves to deal with them.”
Bill Gates and pharmaceutical companies and governments have undertaken this ‘vaccine race’, but I question whether this is the right action given most people are unlikely to be too adversely affected by this virus.
Certainly take steps to protect the vulnerable, but it seems there has been great reluctance to find and acknowledge effective treatments and preventatives such as vitamin D – why? Is it because this would have disrupted the race for lucrative vaccine products to foist on mass populations?
We need to look at the big picture on this, particularly at the entire vaccination schedule over life, this has grown hugely in the past few years, look at the Australian schedule for example: https://www.health.gov.au/health-topics/immunisation/immunisation-throughout-life/national-immunisation-program-schedule
There’s an expectation of a ‘magic bullet’ for every ailment…well I’m suspecting things are coming unstuck, and we need a close look at individual vaccine products and revaccinations, we have no idea of the potentially deleterious effects of the ever-increasing vaccine burden throughout life.
It’s a very serious matter that this area of public health policy has been colonised by the vaccine industry, with people who work on vaccine clinical trials also being on government committees which make recommendations about vaccine products for taxpayer-funded schedules, there’s a morass of conflicts of interest.
Again, we need to look at the big picture on this, and in my view the plan to vaccinate the entire global population against this coronavirus, potentially every year, is wrong.
Why have we all got to become vaccine junkies to make Pharma more wealthy? Since when did our own immune systems become incapable of protecting against viruses? Also, have you looked at the chemicals in these vaccines and determined if they are detrimental to our health? – do they cause dementia, inflammatory disease? Have these types of ‘vaccines’ gene therapy ever before been used in humans? In animal trials, did this type of gene therapy lead to pathogenic priming? Finally, HAS THE WORLD GONE MAD, TO MASS INJECT ENTIRE POPULATIONS WITH NEW TECHNOLOGY WITH NO PHAMA LIABILITY AND NO LONG TERM TRIALS WITH GOVTS EXTRACTING ‘CONSENT’ FROM POPULATIONS WHICH IS NOT INFORMED CONSENT – ALL THIS! . . . FOR A FLU VIRUS?!!! . . . . NOT A HIGHLY CONTAGEOUS INFECTIOUS DISEASE BUT . . . FLU?!
I SO agree with you!!!
You are absolutely right.
The world is gone mad ,they have convinced almost every body that everyone is ill unless there is a test that said that he/she isn’t.
Dr Rusthworth follows the covid -19 narrative with a naivety .
Agreed. There is now research that describes a vaccination issue similar to the problem of overuse of antibiotics leading to antimicrobial resistance.
As a vaccine triggers a specific antibody response, natural immunity is suppressed. This leaves one vulnerable to variants. He posits it would not take much for the virus to mutate such that large swathes of the human population whether vaccinated or not are at real threat. He urges immediate and further research into vaccines that trigger NK cell responses (not B & T cell ones as per current choices) as these have shown far greater efficacy in research so far.
Ironically he blames human intervention for the mess but his solution is still human intervention. Still, that is how science progresses, I guess.
I would encourage early intervention medications and treatments for Covid patients who are vulnerable. This is the only time we are sent home to drink chicken soup and all medications are not allowed to even be discussed. This is how Fauci treated HIV back in the 80s, recommending no treatment until a vaccine is found. We have medications for HIV but no vaccine. Any suggestion of early intervention medication such as Ivermectin, HCQ+Zn or if worsening conditions, monoclonal antibodies are immediately CENSORED. Why? So oily vaccine salesmen can make a fortune? But let’s remember exactly who got that vaccine out, to the extent that the government agencies demanded it: Pres. Donald Trump, who managed Operation Warp Speed. Can you imagine Joe Biden trying to organize anything at all, let alone a national vaccine program in 9 months?
Sebastian, It is important to be precise in stating whether the vaccines prevent COVID infection. None of the trials measured this, because not everyone was tested. They only measured COVID in those people who were symptomatic. So it is entirely possible that the vaccines increased the incidence of asymptomatic or minimally symptomatic infection.
This comment aged well, considering that Pfizer execs are now admitting they didnt test for disease transmission. (Nevermind that some of the Pfizer test sites were possibly corrupt or fraudulent.)
Thank you for an wonderfully informative article. My only question is related to auto immune disorders. I have an underactive thyriod and take 175mg thyroxine a day. I have done so for over 20 years now, so it is “normal” for me, but with the advent of the vaccines suddenly the question of auto immune disease makes me see my underactive thyroid in a different light. I’m guessing I should think long and hard for now about whether to take a vaccine as I understand hypothyroidism is an auto immune disease.
An underactive thyroid can be due to many different things. The most common cause is Hashimoto’s disease, which is an autoimmune disease.
Hi. I am liver transplanted 11 years ago, and for this reason, I eat imunesuppressive medicin, Advagraf, dose is 2,5 mg/day. This dose is seriously checked 4 times per year, and I have had the same dosis from the day of transplant. And – I have not had any rejection problems at all with the ”new” liver, which is a FAP patience liver. FAP is Familiar Amyloidos with Polyneuropatie.
As the vaccine studies does not include persons with immune suppressions, could it then be possible for me to take the vaccines? I have earlier taken vaccines against the season flu without problems.
I think this topic is interesting, as there arel quite a big number transplanted people in the world.
The reason they exclude people who are immune-suppressed from the study is because they are less likely to develop good immunity after taking the vaccine (which is different from people who have an auto-immune disease, who are excluded because they are more likely to have a bad reaction to the vaccine). So, if you’re immune suppressed, the vaccine is probably not more likely to cause side effects than it is in the general population, but it’s less likely to be effective.
On the topic of vaccine safety, The New York Times recently published an attack on Robert Kennedy Jr, by his niece Dr Kerry Kennedy Meltzer, titled ‘Vaccines are safe, no matter what Robert Kennedy Jr. says’.
I wrote to the Editor of The New York Times complaining about this poorly informed article by a doctor who admits “Being a doctor does not make me a vaccine expert”.
My email also includes reference to the current rushed rollout of coronavirus vaccine products, and to the influence of Bill Gates, including his sabotaging of the mooted US Vaccine Safety Commission, which is interesting to consider now in light of the increasing number of coronavirus vaccine products racing to market…
My email to the NYT Editor is accessible via this link: https://bit.ly/3pY4DLv
Interesting email. You sign off with ‘Independent person investigating the over-use of vaccine products and conflicts of interest in vaccination policy’. Do you publish / post your findings anywhere?
Thank you so much for this detailed article. The subject of Covid vaccines is one that has been worrying me greatly – mostly not that it may it become mandatory but that the development of vaccine passports may make a relatively normal life difficult. However, I realise that that is not what this article is about.
I last had a vaccine – rubella – when pregnant with my first child. That child is now 32. I have never had a flu vaccine and am sure that I haven’t had flu for 36 years (I remember being ill (maybe not even flu) when I was engaged to be married but nothing since then and I’m told that one doesn’t forget a bad dose of flu.
I am not anti-vaccine but I feel that it is important to weigh up the risk versus the benefit. I am 65 but metabolically healthy with good Vitamin D levels. My only health condition is an underactive thyroid as a result I believe of Hashimoto’s for which I take a thyroid medication. Although my thyroid antibodies are normal now, the lack of evidence of safety in those with autoimmunity would worry me especially as I believe the risk of having subsequent autoimmune disease is higher in those already having one.
Thank you again for your very detailed articles – so good to have a reliable source of information.
Thanks for this interesting review. Do you have an opinion whether vaccine or infection provides the best future protection?
Most likely you will get better immunity from real infection than from the vaccine. There are a few examples of vaccines that provide better immunity than the actual infection, but in most cases real infection induces better immunity.
What do you think is a better way to get immunity: Infection or vaccination?
Thank you so, so much for this information. Very informative and balanced.
Are you looking at the use of Ivermectin at all, which appears (from what I have read) to be effective against Covid, although I am definitely no expert. It would be good to have a trusted unbiased view on its use if you have the time to comment on it at some point.
Thank you once again for all your time and effort in producing this post, and all of your others too.
That’s the next topic I plan to dig in to 🙂
Thank you for yet another excellent article. You do a great public service. It’s really disappointing that the regulators presumably approved such poorly designed studies.
I learned today via Twitter of an opinion piece in the BMJ by an associate editor of the publication, reporting on his analysis of the Pfizer data. He has spotted something that casts some doubt on the efficacy of the vaccine and requires investigation. The salient part of his article is probably this bit:
“All attention has focused on the dramatic efficacy results: Pfizer reported 170 PCR confirmed covid-19 cases, split 8 to 162 between vaccine and placebo groups. But these numbers were dwarfed by a category of disease called “suspected covid-19”—those with symptomatic covid-19 that were not PCR confirmed. According to FDA’s report on Pfizer’s vaccine, there were “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 occurred in the vaccine group vs. 1816 in the placebo group.”
With 20 times more suspected than confirmed cases, this category of disease cannot be ignored simply because there was no positive PCR test result. Indeed this makes it all the more urgent to understand. A rough estimate of vaccine efficacy against developing covid-19 symptoms, with or without a positive PCR test result, would be a relative risk reduction of 19% (see footnote)—far below the 50% effectiveness threshold for authorization set by regulators. Even after removing cases occurring within 7 days of vaccination (409 on Pfizer’s vaccine vs. 287 on placebo), which should include the majority of symptoms due to short-term vaccine reactogenicity, vaccine efficacy remains low: 29% (see footnote).
If many or most of these suspected cases were in people who had a false negative PCR test result, this would dramatically decrease vaccine efficacy. But considering that influenza-like illnesses have always had myriad causes—rhinoviruses, influenza viruses, other coronaviruses, adenoviruses, respiratory syncytial virus, etc.—some or many of the suspected covid-19 cases may be due to a different causative agent.”
You can read the full article here: https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/
You can find an analysis of Peter Doshi’s opinion piece here: http://hildabastian.net/index.php/covid-19/103-unpacking-doshi-take
So Peter Doshi caught the huge fuzzy hole in the study even back then, which is that it did NOT prove that the injection prevents infection (and hence transmission) in a majority of cases.
As you know, Pfizer execs have admitted, almost two years later, that their product was never tested to see if it prevented transmission, angering millions of people who were subject to mandated injection.
Thank you for a great review of the three vaccines. Cases of serious adverse events are coming in now on Moderna’s vaccine too. Am american healtcare worker and family are reporting convulsions all over the body, including the toungue. She is now in hospital. You can llok up her case on facebook. Her name is Shawn Skelton. She has made her status updates open to the public in order to warn others.
A concern to me is the role vitamin D plays in the immune response. These trials were all conducted over the summer months when vitamin D levels are at least likely to be higher. The vaccine is now being delivered to a population that we know likely is less likely vitamin D replete, and will the vaccine effectiveness be diminished. Time will tell. The severe disease is almost always in D deficient individuals.
Steve Park MD, retired obesity medicine
Thank you, Dr. Rushworth, for this detailed analysis. My view is run for the hills and hide the children (I’ll be 72 shortly).
I wonder whether the studies could address these concerns which I picked from Dr Wodarg’s website:
” The formation of so-called “non-neutralising antibodies” can lead to an exaggerated immune reaction, especially when test persons are confronted with the real, “wild” virus after vaccination. This so-called antibody-dependent amplification, ADE, has long been known from experiments with corona vaccines in cats, for example. In the course of these trials, all cats that initially tolerated the vaccination well died after being infected with real corona viruses. This overreaction is further encouraged by potentiators.
The vaccinations are expected to produce antibodies against spike proteins of SARS-CoV-2. However, spike proteins also contain syncytin-homologous proteins, which are essential for the formation of the placenta in mammals such as humans. It is essential to rule out the possibility that a vaccine against SARS-CoV-2 could trigger an immune response against syncytin-1, otherwise infertility of indefinite duration could result in vaccinated women.
The mRNA vaccines from BioNTech/Pfizer contain polyethylene glycol (PEG). 70% of people develop antibodies against this substance – which means that many people can develop allergic, potentially fatal reactions to the vaccine. ” https://www.wodarg.com/english/
What do you mean with a “better immunity” for real infection compared to vaccine? Is that a stronger, longer or a wider range of protection?
Higher probability of immunity, and longer lasting immunity.
Thank you for yet another great post!
I have a question about auto-immunity and vaccination. Personally, as of yet, I don’t have any auto-immune disease, but blood tests have showed that I have elevated levels of anti nuclear antibodies, ANA (1/80). Does that mean that I have a higher risk of developing auto-immune disease after a vaccination and would you therefor advice me from not taking these vaccines?
Thanks in advance!
Hard question to answer, probably best to direct that question at a rheumatologist.
Thank you very much for your work and blog. I have also read a piece by Dr Zoe Harcombe about the vaccine trals and one thing I remember is her comment re. the numbers who did not catch Covid at all in the trials. Is the big picture, that this virus has been and gone to a large extent? That wouldn’t suit the politics of today of course, so it has to hang around until it’s served its purpose.
‘The tiny number of people who tested positive is striking. The revised Pfizer numbers could also be reported as 99.9% of people in the vaccine group and 99.1% of people in the placebo group didn’t test positive. The Oxford/AstraZeneca numbers were similar. Out of the 11,636 people included in Tables 1 and 2 (December paper), there were 131 total cases. That means 98.9% of people overall did not test positive. That was split between the vaccine and placebo groups as follows: 99.5% of the vaccine group and 98.3% of the placebo group didn’t test positive. In May 2020, there were discussions about the ethics of whether or not vaccine volunteers should be deliberately infected with the virus because so few people were catching it naturally, and vaccine trials were at risk of not having enough cases to study (Ref 14).’
Hej Sebastian. Thank you for the great article again!
I have a question regarding transmission. Where there any signs in the studies of vaccinated people transmitting no or less virus to the next person?
That hasn’t been looked at in the studies, so there is no information on that.
AZ protocol, exclusion cit., page 37: https://s3.amazonaws.com/ctr-med-7111/D8110C00001/52bec400-80f6-4c1b-8791-0483923d0867/c8070a4e-6a9d-46f9-8c32-cece903592b9/D8110C00001_CSP-v2.pdf#page37
Dear Dr Rushworth,
Thank you for your much-needed assessment of vaccine safety and efficiency.
My concerns are well articulated above by Kora Klapp, those being the long-term effect of what I perceive to be under-tested vaccines using unauthorised genetic-modifying technology which is capable of inducing an immune over-reaction which could lead to organ failure and possibly death. It seems to me that the whole world is being coerced into a giant medical experiment.
This concern is in addition to analysis by others that suggests the vaccines will not stop infection, transmission, hospitalisation or death.
As a 74-year old with (well controlled) astma but otherwise being quite well I will shortly be offered the jab. Despite your excellent article, I stlll do not know which way to jump on this. Hopefully I can decline the invite and opt for a “wait-and-see” strategy.
Håkan: We do know with measles that immunity is lifelong. Virtually everybody in my cohort got it. Interesting paper from Japan showing significantly lower rates of CVD in those who had had both measles and mumps. I can post the link if you’re interested.
These are the (peer reviewed) results from continuing clinical trials that has not been completed?!
Or is this Off-Guardian article referring to other studies?
Yes, that’s correct. Technically the trials are going to run for a few years, so the results that have so far been published only cover the first few months. But no-one’s willing to wait two years to start vaccinating people against covid…
Good Morning Sebastian,
Thank you for another very informative article. As a 73yr old with celiac disease I am somewhat hesitant to take the vaccine at this time though I am being urged by family members to take it ASAP, here in Southern California maybe in a month or so. I have had no problems with other vaccines i.e. pneumonia, flu and shingles, so hopefully I would not have a problem with the Covid vaccine!
Thank you for this detailed article as I feel I am better able to understand how vaccines work and what to look for in study’s now for efficacy and safety.
Can you also help me understand if taking a vaccine is going to ultimately stop the spread of the disease? My nursing friends are posting themselves getting the vaccine on social media and saying things like, “I’m getting this for you. To keep you safe.” Also, in the states our Surgeon General and others are saying to keep wearing your mask and social distancing even if you get the vaccine. Can you help me have some clarity on this? I need some help working through my thoughts on this.
Thank you. Keep up the great work.
At present there is no evidence that the vaccines prevent spread of the disease. It’s likely that they do, but it hasn’t been shown yet.
The inclusion of Brazilians in the study groups put me in mind of this.
I don’t speak or read Portuguese. But the upshot seems to be a large group of patients with significantly reduced symptoms as a result of HCQ.
What always was and is needed against Covid19 is a drug and/or a prophylactic treatment, not vaccines.
Both existed and exist, if only a fraction of the money we wasted sofar had been spent on proper, mass RCTs for them, instead of or in addition to the vaccines, we would have done the proper thing and done and do much better.
But then, it seems more and more that this has never been and still isn’t primarily about health…
Absolutely brilliant and valuable analysis. Thank you for your very-helpful sober, objective writing/blogging.
Dear Sebastian, thank you very much for summarizing these studies and pointing out the flaws. I adore all of your content. With this post I’m curious about to what you’d ascribe the flaw present in every study: that only mostly-healthy people and few aged were included. Surely it cannot be incompetence in three separate top-studies. Would you bet on lack of resources, malice, something that you might have missed, or something else?
I think the main reason was that you’re more likely to get a good immune response from younger, healthier people, so the vaccine will appear to be more effective.
Thankyou Sebastian. My issue is with your reported incidence of Grade 3 SAE’s in the Moderna vaccine group, which you cited as 1%.
From the NEJM report of the Moderna trial:-
“The severity of the solicited systemic events increased after the second dose in the mRNA-1273 group, with an increase in proportions of grade 2 events (from 16.5% after the first dose to 38.1% after the second dose) and grade 3 events (from 2.9% to 15.8%).”
There is a big difference between 1% and 15.8%!
In addition to these solicited events, there were a further 1.2% of Grade 3 unsolicited events in the vaccine group.
Which, by my calculation, suggests that 17% of trial subjects in the vaccine group experienced a Grade 3 adverse event.
In addition, there were a handful of Grade 4’s.
Am I missing something?
The 1% number is serious adverse events, table S11 in the appendix, not grade 3 adverse events. A grade 3 event can just be a high fever, which is quite common after vaccinations. That’s why I focused on serious adverse events instead.
The group at greatest risk of death from Covid is, strictly speaking, not those persons merely 75 years old and older but rather those of them who also have serious underlying chronic illnesses — that is to say, persons with one foot in the grave. And since those persons, if I understand correctly, were excluded from the studies, little or nothing can be known about the safety or effectiveness for them of any of the three vaccines. Moreover, among those persons 75 years old and older who are in good health, the rate of recovery from Covid, absent a vaccine, is estimated to be between 85% or so and 94%.
Great article – but see Peter Doshi’s article on the FDA submissions for the Pfizer vaccine and see if you still think it was a decent trial!!
Thank you Sebastian for another excellent post! You remain one of the very few sane voices in a world that has now gone completely crazy! I share the concerns expressed by others in previous comments, and to me, this is first and foremost an “anti-fear” vaccine for all young and healthy people that are acting as Ebola is spreading across the globe… I just hope that they’ll start living again after they’re vaccinated, for us all to try to repair the long-term damage to society that this has caused!!
Skeptic Al: Wise decision. The fact is, none of these vaccines are necessary. There are at least three treatments which are highly effective given prophylactically or in the first few days of symptoms. The push to vaccinate the entire world originated not from scientists or doctors, or even governments, but from a college dropout eugenicist named Bill Gates.
And it doesn’t sound at all ethical to give a meningococcus vaccine instead of a placebo without a person’s knowledge and permission. Very concerning.
Yes, I’m interested in the mentioned study so please post a link.
Gary, as a mother of 4, that’s exactly what I’m feeling.
George, absolutely correct. I look forward to Dr Rushmore’s research on ivermectin.
Do we really know how many individuals have been included in the study so far? E.g. the Astrazeneca study has an estimated primary completion date on March 12, according to clinicaltrials.gov. And that is when they give the last participant a shot, isn’t it?
And can estimated primary completion date be on the same date as estimated study completion date?
Actual Study Start Date : September 2, 2020
Estimated Primary Completion Date : March 12, 2021
Estimated Study Completion Date : March 12, 2021
Thank you for breaking these studies down for us. I do not doubt the veracity of the studies or the sincerity of the researchers but everyone from the drug companies, governments, regulators, media and most of the public want these vaccines to work and to work now. These are not good incentives to have for vaccine development because we might miss some adverse effects or do not thoroughly test for efficacy in older or sick people.
I stay with my goal to not take the vaccine. I am a healthy (if a bit stressed out right now) 40 year old male with no diabetes, obesity, lung or heart disease. I would consider this vaccine maybe in the next two years if SARS-COV2 turns out be a seasonal disease like the flu and the vaccines turn out safe after two years of use. But I did recommend taking the vaccine for some 70+ family members who do have some underlying conditions.
George Berger: Correct. It has never been about health. The purpose is massive profits for the pharmaceutical industry and the very wealthy, collateral damage be damned. There is simply no need for a vaccine for coronaviruses. As Dr. Rushworth notes, we’ve had millions of years of evolution with exposure to multiple types of potentially pathogenic microbes for our immune systems to learn how to live with them in health. The key here is health. If only 12% of Americans are metabolically healthy (insulin sensitive), what about the rest of the world? I maintain that those in good health have essentially zero risk of serious illness from any coronavirus, and that medicine has gone off the rails (long ago) treating sickness rather than promoting health.
Håkan: Here it is:
Tish: Nearly all vaccine trials have used either another vaccine or the vaccine minus the antigen for the control group. The only reason Pfizer used saline was because they were forced to, after a lawsuit by ICAN. Actually the meningococcal vaccine has a problematic safety record. It is not widely used in the U.S. There is an article on Children’s Health Defense about it. As I understand it, about 20% of the population are carriers of the bacterium, but the disease is rare.
Håkan: According to Dr. Kendrick the AZ trial will be completed in February, 2023.
Thank you Dr Rushworth for a brilliant article.
Am I no Dr – only a familyfather finding all this vacineprogram “too good to be true” and dont by their story. So good you can explain it so I can understand.
What really consern me is the effect on reproduction and infertility. Do they say anything about it – are there any prospects or thoughts ? Can I ask what you think ?
Best regards André Jenssen
Hi André, there is no data on that available so far. I can’t personally see any reason why fertility would be affected.
Eight months later, I believe the concern is that spike proteins are instrumental in the production of the placenta and the concern is the vaccine will interfere or disrupt this process.
I think you meant to say, “the VACCINE will appear more effective.”
Thank you so much for taking the time to write these articles! I find they all very informative in a time when it is difficult to obtain accurate information on these important topics.
Thank you, yes, you are correct!
Thanks for the interesting comparison. In Italy there is a lot of talk about the obligation to reach the herd immunity threshold. What do you think about it?
So the vaccines don’t prevent Covid and only lesson the symptoms. Why would I take a vaccine when I have a 99.7% of surviving Covid?
Also addressed here: https://pubmed.ncbi.nlm.nih.gov/33113270/
Andre Jenssen: Pregnant women and those nursing were excluded from the trials, as they are in virtually all trials for drugs and biologics. Female participants had to have a negative pregnancy test both on enrollment, and on the day they received the vaccine. So there is no data. Yet in the U.S. pregnant women are pressured to have both the flu shot and the DTaP (or TDaP). With no data at all.
Emilia: Thank you for posting that. Russian roulette.
A sobering story about a trial participant: “Yesterday, I was speaking with a friend who teaches Zumba…she asked me (me!) what I thought about the Covid vaccine. Then she went on to tell me that one of her students, a healthy, woman who was able to sail through a rigorous Zumba class had been part of the Pfizer trial. And she has fallen down twice in class, since the clinical trial.” — https://www.ageofautism.com/2021/01/sharyl-attkisson-reports-on-health-impact-events.html
A common vaccine injury, especially in children, is damage to the brain stem, which affects facial muscles, balance, vagus nerve integrity, etc. The Zumba student could have had a brain-stem injury from the vaccine affecting her balance. No one knows 🙂
We also don’t know what the effect of these vaccines is to nerve/brain health. No one has done before/after studies of reaction time, balance, mental acuity. Forrest Maready has an interesting book about brain-stem damage from vaccines, Crooked: Man-Made Disease Explained.
A site tracking COVID vaccine injury: https://hpv-vaccine-side-effects.com/covid-19-vaccine-side-effects-world-map/
Hi Simon. FDA’s definition of a Grade 3 is; “Grade 3 Severe or medically significant but not immediately life- threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care ADL”
To me, that constitutes serious! I am more used to oncology trial reporting, where it is standard practice to collectively quote incidence of SAE’s Grades 3-5. All are deemed serious. This report also states that the incidence of SAE’s is greater amongst those under 65. So those at lesser risk from Covid have perhaps a 1 in 5 chance of a ‘Severe or medically significant but not immediately life- threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care ADL’ adverse event…..
I am great fan of your work and appreciate all you do. But I cannot agree with the unqualified ‘safe’ conclusion. Thoughts?
I like the question ‘Is immunity via actual contagion more effective than via vaccination’ (although definitely not as profitable for the industry!) – It will be interesting to see how any adverse reaction to vaccine compares to natural infection where zero reaction has meant most have to be tested to know they have actually been infected (It is so weird that ‘not being able to tell if you are infected’ is the outstanding characteristic of a World stopping pandemic. Wonder if there will ever be such a benign pandemic again) – Retrospectively realised I had all the gradually revealed in the media symptoms in February so hopefully that was it and so presumably now have immunity to the original and likely some immunity to mutations as per the common cold Covid?
“From three weeks after receiving the first dose of vaccine, there were 10 hospitalizations for covid in the control group and zero in the vaccine group… That is impressive”.
“In total, there were 79 serious adverse events in the group getting the vaccine, and those adverse events are evenly spread out among lots of different types of event, the vast majority of which could not possibly have anything to do with the vaccine”.
I am not sure quite how anyone can be certain that a serious adverse event “could not possibly have anything to do with the vaccine”. However, passing over that, it seems that some people suffering serious adverse events were not hospitalised. Does that mean those events were not really very serious after all? Or that someone decide that no one from the vaccine arm should be hospitalised because it would look bad?
Hello Dr. Rushworth, What is your opinion about the possible longterm effects of these proteins proliferating in the body?
I would say that isn’t possible. The viral genes are broken down in hours to days at most after injection in the body. Especially mRNA is highly unstable (the reason it needs to be stored at low temperature) and degrades very quickly.
Do you say it isn’t possible because you have clear evidence that it isn’t possible – or because, based on what you know, you cannot fathom a mechanism by which long term effects could occur?
If the latter, do you think that such confident speculation (for that is what it is in the absence of evidence) is warranted in the case of the new mRNA vaccines? Why? Given our lack of evidence on the use of mRNA technology in humans, I think that it is important to remember that we don’t know what we don’t know.
As you yourself pointed out in a separate article that I just read, what makes sense to us and what is correct aren’t necessarily the same.
Lindsay. A kinesiological test shows that you are immune. (Who the heck believes in such tests?). Feel confident:
Be careful with such questions or opinions! Bill & Melinda Gates, Fauci, Google, Apple, Facebook and Twitter are united in an unholy alliance in allowing only one official opinion which one with which they agree. We are in the Era of Covid-1984. If you decide not to have the vaccine you may be “cancelled.”
Thumbs up! Are you even allowed to have such an opinion, let alone express it?
Dear Sebastian, thank you for your interesting article. If in the future you would like to consider writing about Ivermectin please consider also writing about Amantidine. Here in Poland some doctors achieved very promising results for curing even severe cases of Covid within 48 hours. Some results of the successful application of this substance were also reported in some publications from Mexico, Spain, UK, and Turkey. After first promising results of using Amantidine (medicine name Viregyt-K) our government suspended sale from drug stores in the whole country (it was really surprising) then one vice-Minister fell ill and received this medicine. After short time he recovered and then asked Health Officials and Ministry of Health why it was suspended? Fortunately, it is again available in drug stores.
Very thorough but readable and as such enormously helpful article, thank you.
What is your view on mRNA/vector DNA/DNA vaccines compared to traditional ones in general?
Are you not concerned about the unknowable medium to long term side effects of them, what could they be and when would you expect them to occur?
Isn’t the low number of positively tested (0.4% Pfizer) in itself creating just a random result here?
A new shampoo’s survey seems to have bigger numbers and as such more credibility…
Don’t those low numbers of infected suggest that vaccines offer a very small absolute risk reduction, as some have already observed and calculated, and that they are therefore really pretty much unnecessary, certainly for anyone not in an at risk group?!
I’m not that concerned about the technology as such, the genes in the vaccines are the same genes you would get exposed to if you were infected.
As to the low reduction in absolute risk – normally I think that is a valid point, but since we expect most people to become infected over the course of the coming year, it makes more sense to look at the reduction in relative risk.
A very useful analysis of those vaccines. I would like to see your comment about the FCCC Alliance (https://covid19criticalcare.com) initiative for the use of ivermectin to prevent COVID-19 disease move to the inflammatory phase. The 10min address by Dr. Pierre Kory at the US Senate hearing is poignant https://www.youtube.com/watch?v=YgOAaLmoa68&t=81s Published material about ivermectin is been collected here: https://ivmmeta.com
This video is removed from You Tube
Do you know why?
No doubt because IVM really works… shameful! If you use the name of Dr. Kory or Dr. Marik you should recover a video. For example, I just got https://www.youtube.com/watch?v=PXh1yflndVE&t=1409s
Your questions are valid and represent many people’s views. I would add that we are missing an opportunity to educate the public on immune enhancing lifestyle and nutrition preventative measures (like the vitamin D mentioned). At least in the US, policy and recommendations seem to encourage poor health and a compromised “terrain” rather than improve our chances of survival, thus making us more dependent upon synthetic forms of prevention. Also I wonder how vaccines compare to natural immunity which is created by actually contracting the disease. A comparison three months out between those getting the vaccine and those who have already developed the disease would be enlightening. Actually 3, 6, 9, 12, 24 months post vaccine/disease would be very helpful.
Thank you Dr. Rushworth, for another excellent article. I’m healthy, not at all afraid of catching this “cold”, and have no intention of taking any of these experimental vaccines. The problem is it’s starting to look like even if the vaccine is not mandatory, people who refuse it will not be able to live a normal life. All sorts of restrictions from not being able to board a plane or public transit, get a job, to even being denied entrance to a store or restaurant have been suggested. Do you think these things are likely to actually happen?
When getting the vaccination, people have no options or choices about which one will be provided, so although this article has been so helpful (thank you!) the specific recommendations about which ones might be worthwhile and safe have diminished benefit when no choice is presented other than to have or not to have.
Given we are lied to on a daily basis, how can we be confident that the results being reported from any of these vaccines are not also lies?
There are few things that just do not add up https://www.wired.com/2003/05/feds-race-to-make-sars-vaccine/
yes alisonfletch, its indeed surprising how good the immunesystem competes with those vaccines, it makes me think why do we need a covid or corona vaccine at all.
Thanks for another great article Dr Rushworth. I learned a lot.
Question. Wouldn’t it be wise to try to preserve vaccines for those who haven’t already been infected / developed natural immunity? But how would you go about determining who those people are, given that a minority of people appear to produce detectable antibodies in response to infection?
I agree, it doesn’t really make much sense at present to give the vaccine to people who have had a confirmed covid infection and have measureable antibodies.
Above you say in a reply:
“As to the low reduction in absolute risk – normally I think that is a valid point, but since we expect most people to become infected over the course of the coming year, it makes more sense to look at the reduction in relative risk.”
Could you not also use that argument to promote the seasonal influenza-vaccine to be given to the whole population and not just risk-groups and health workers? Is that really a valid argument in this situation, i.e. with a virus that doesn’t appear to be that much more severe than Influenza?
If it is true what J. Couchman quoted above in his reply:
“All attention has focused on the dramatic efficacy results: Pfizer reported 170 PCR confirmed covid-19 cases, split 8 to 162 between vaccine and placebo groups. But these numbers were dwarfed by a category of disease called “suspected covid-19”—those with symptomatic covid-19 that were not PCR confirmed. According to FDA’s report on Pfizer’s vaccine, there were “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 occurred in the vaccine group vs. 1816 in the placebo group.”
Then wouldn’t it be more interesting to diagnose which pathogen caused most of those ‘suspected cases’ and find a vaccine against that?!
And as I commented before: a positive PCR-Sars-cov-2-test does not rule out the causative agent of the disease to be something else (influenza, RSV, rhinovirus, ‘common’-corona, …), so not ruling out other causes of the non-specific symptoms is actually a big confounder in these studies I would say. It is easily imaginable that someone catching Sars-cov-2 and getting symptomatic is also vulnerable to becoming symptomatic of other viruses, to name but one possible relation.
As with someone with a pneumonia: just because you can PCR pneumococcus from his/her upper respiratory tract (URT), that doesn’t mean it’s also the bug causing the disease, since there are others just as likely to cause it. Many of us are colonized with pneumococcus in the URT so just proving that would/should normally not be adequate to decide with which antibiotic you (start) to treat with… Nor to name it as the causative agent of the diagnosed pneumonia.
So I would add that to the list of confounders in the study: not ruling out other pathogens when having symptoms and suspecting covid19 but exclusively relying on a positive PCR test for Sars-cov-2 in the URT.
And about your article: despite your questions about the design, methodology and outcome of the studies: you dó think the published results to be trustworthy? After everything last year: the misinformation by organisations, governments and media, with the known large-scale manipulation of studies and results by pharmaceutical companies in the past, the huge rush for a vaccine and the enormous pressure and expectation for it to be succesfull: you still trust the published results?
Call me a sceptic, but just out of rational caution I would advise everyone to wait a while longer and ask for more and better data…
And not just concerning the vaccine but concerning the whole ‘threat’ of the virus itself.
Because in the end, there is still the cost/benefit analysis to be made: is the investment and implementation of a vaccine really outweighing the harmfull effects of the virus?
A wild guess: ending any lockdown a month ‘too early’ might give more benefit to our societies health-wise (overall, so including everyone under 70 years of age and not just focusing on covid-19 related health-events) and cost-wise than carrying on with lockdowns and trying to get everyone vaccinated during them…
Keep up the good work!
You make many good points. I do agree that it would have been good to test people who were having symptoms with a full viral panel, rather than just testing for covid, to further increase the certainty of the diagnosis. I guess the companies didn’t want to do that for whatever reason (most likely for financial reasons).
As to the suspected covid cases in the Pfizer trial, I haven’t dug in to that but assume that these are cases where people had respiratory symptoms but a negative covid PCR. I’m not sure too much should be made of that, because even in the era of covid most respiratory symptoms are caused by other pathogens, so those “suspected covid” cases probably aren’t covid cases at all. I do agree that it seems a bit ludicrous that we’ve poured all this money in to making a vaccine against one respiratory virus when there are a hundred others that we’ve known about for decades and never bothered to try making a vaccine for.
When it comes to trusting the data, well, I trust that the numbers in the tables are not made up. As I’ve said before on this blog, if we can’t even trust the numbers in the results tables, then there’s really no point pretending that anything we do in medicine is based on science.
ADE. Check out Prof. Delores Cahill. COVID-19 informed consent. Very interesting.
The cycle level of the PCR tests administered are not included in this article. As you know, if cycled over 30, then everything from flu and cold live and dead viruses can be identified as a positive COVID-19.
Hello. Thank you for your work, always pleasant. Have you dug up the additional data published by Pfizer and Moderna? (I don’t know if the general public has access to it). They seem to contain a few surprises that need to be clarified. This article is interesting because one of the data seems to suggest/confirm that 90% of PCR tests detect false positives (among others). https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/
Very informative and comprehensible text. What is your opinion on this comment:
You can find an analysis of Peter Doshi’s opinion piece here: http://hildabastian.net/index.php/covid-19/103-unpacking-doshi-take
Pfizer Trial: Severe cases of covid: 1 in vaccine group, 9 in placebo group. These are far too few cases for a valid statistical answer. Even Pfizer acknowledges this giving a confidence intervall of “-152,5% – 99,55%”. Such a large confidence intervall, basically, means “anything can happen”. Or: the data are meaningless from a statistical point of view.
If you want to take these numbers seriously it gets even worse: The -152,5% means that it is more probable to get seriously sick if you are vaccinated than if you are not.
Worst: The 1 severe case of covid which occured in the vaccine group happened after the second shot and after a 7 days waiting period. That`s exactly when the vaccine is supposed to become really effective.
As with Pfizer, to evaluate the efficiency regarding “severe cases” percent numbers are meaningless unless you can compare them to the absolute numbers.
There were no cases of hospitalization, no cases of death in the Pfizer trial. So no data about this.
What you are quoting as efficency is the relative risk reduction. In absolute terms this looks a lot less impressive:
No. of people who did not get Covid because of vaccine 153 x 100 : all vaccinated people 18.198 = 0,84 %.
Normaly a vaccine against a virus like Sars-Cov-2 (Corona family) or any other vaccine against influenca should be tested during the months where these sickdoms are most likely to strike, meaning in winter. Not done here. So all these numbers are very likely to change. In what directions? Well, nobody knows. No data.
Pfizer, WHO etc. all agree on 1 subject: It is still unknown if these vaccines
prevents people from being contagious. Meaning: Vaccinated people may get infected but without developing symptoms, such being still contagious carriers of the disease.
In the supplementary appendix, Pfizer lists a 95% confidence interval for the size of the reduction in severe covid of from 20.1%-99.7%. Where did you find the confidence interval that you’re referring to?
I’m not sure if I am asking the correct question, or even asking the question correctly, but something isn’t sitting right with my, admittedly layman, brain.
If vaccine vs placebo participants go on to test PCR positive, with at least one clinically diagnosed symptom, how do we know they weren’t going to go onto to become ‘positive’ regardless of the intervention? How do we know that it was in fact the vaccine that reduced the chances of developing symptoms or that there were just more people who happened to be in the control group that were going to go on to be ‘positive’ anyway?
That problem should be avoided by the fact that the study uses a randomized design. If the vaccine doesn’t work, there should be roughly as many people diagnosed with covid in both groups. The fact that there is a big difference between the groups makes it highly improbable that the difference is just due to chance.
If the vitamin D status of the trial participants had been measured at the start of the trials …would those who then developed covid be more likely to have had lower levels vitamin D?
did a vaccine prevent/ reduce illness or did a high vitamin d status ?
Rich G: Excellent question!
Israel and the UK have already vaccinated millions of people with Pfizer, and other countries are ramping up fast. I guess that if serious reactions are somewhat common, we will soon know.
Insightful piece, as usual. But, wouldn’t you consider get vaccinated for altruistic purposes?
If I do get vaccinated, it will be entirely for altruistic purposes. I’ve been working closely with covid patients all year and still haven’t been infected (as far as I know – I’ve taken two antibody tests that were both negative and also two PCR tests that were both negative over the course of the past year), and I’m (relatively) young and healthy, so I’m not even remotely worried about covid personally.
But not entirely improbable and not measurable? I thought that might be the answer you came back with to be fair.
For the AstraZeneca trial using the meningococcus ‘placebo’, how do we know this wasn’t a causative factor in the ‘increased’ instances of ‘positive’ participants?
Thanks for taking the time to reply.
Hello Doctor. This was very informative. You said that you WOULD take the Moderna vaccine. But I would highly recommend that you view the following video of a doctor. She goes on about how Moderna has (as she claims) NEVER, not only manufactured a vaccine, but it has never even made a MEDICATION of any kind! Thus, she expresses her concern over the expediency of the release of this vaccine. Also, the U.S. the government has granted FULL IMMUNITY to ALL of these pharmaceutical companies from law suits originating from “unintended effects” from the vaccines — perhaps in exchange for their “expediency.” Please watch this video (about 20 minutes long), and let me know what you think and if you STILL would take the Moderna vaccine.
I read with interest the article on the vaccines however I have a query.
I would expect that none of the participants of the testing were directly infected with the Covid virus, so the question is how do we know how many of the test subjects were susceptible to actually catching it?
If 20000 of the 22000 didn’t come into contact with the virus then surely the result become even more questionable?
You are right that most people in the study probably never came in to contact with the virus, however, that effect should be spread evenly between the vaccine group and the control group thanks to randomization. The reason that the study is so large is because they planned it with the expectation that most people in the study wouldn’t be exposed. If instead they actively inoculated people with covid it would probably have been enough to have a few hundred people in the study.
Hello Dr. R.,
Thank-you for your work, and for sharing it.
Personally I’m not anti-vax, as a 50-something, I must’ve had 4-5 in my lifetime and am grateful for them – my child had the additional MMR too.
Saying that, I don’t usually like to put stuff into my body that isn’t of vital importance – except beer of course.
So, I’m thinking that as my risk of dying of C-19, is probably similar to my risk of dying from a poor reaction to a vaccine – I’ll give it a miss.
Having lived in SE Asia 1988 to 2017, I also suspect that I’ve already acquired immunity to coronaviruses. I state this because there is an obvious pattern of very low deaths per million across the region.
How could I prove this – would the NHS test me for T-cell immunity?
Thank you very much for the vaccine article; shame it’s not on MSM like Sky News, in my opinion!
Where are you on the likely effectiveness/possible problems with these 3 vaccines, but especially the two mRNA ones, in regards to the new variants (from Kent, UK and especially the South African variant)?
I’ve heard it said that the mRNA vaccines have the advantage that they can more easily be ‘tweaked’ if needed to be able to more effectively fight off these new covid-19 strains. But it seems quite possible that this could basically also be their Achilles heel… I’m concerned that the new variants might ‘fly under the radar’ of especially the mRNA vaccines.
The UK authorities said over 3 weeks ago that the Pfizer vaccine can easily be tweaked in a couple of weeks if required but I’m unaware of any publicly available info from the UK or elsewhere on a/ if there’s even a problem of effectiveness of the vaccine against contracting the new variants, and b/ if there is less efficacy/effectiveness with the new variants, whether any reduced immunity really can be/has been recovered by ‘tweaking’?
Finally, I have a nagging concern that catching one of the new covid variants may not proffer as full immunity against covid reinfection (other ‘regular’ strains). And if having either caught one of the new strains, or having had one of the mRNA vaccines, could these eventualities lead to a possibly increased chance of a bad outcome in a future (regular strain) covid infection? I am aware that you’ve said the Moderna vaccine has an apparent zero risk of harm, but I’m basically looking at the apparent paradox of Dengue Fever: you get one strain and you’re immune for life, but only for that strain – the bad outcome % is, I understand, worse if you then get one of the other 4 strains… I’d like to know your thoughts on whether you share this unease?
A lot of comments so I don’t know if someone has already posted this
Is it possible that the RNA genomes used in the mRNA vaccines can perform multiple functions? I mean, they are manufactured/synthesized to instruct cells to produce sars-cov2 spike proteins, can they be instructed to perform other functions?
Has Pfizer disclosed where they got the genomes from and exactly what sequences were used?
Obviously I am not a medical professional of any sort so please forgive any misunderstanding or misuse of terminology.
Lastly, is it technically possible to combine molecular robotics with mRNA vaccine technology? I.e. is it possible to manufacture/synthesize lipid nanoparticles that can be controlled by external stimuli for the purposes of releasing a different genome/genetic sequence than that for sars-cov2?
I don’t think so – the RNA sequence in the mRNA vaccine codes for one specific protein.
A lot of the problems stem from the pegylated (polyethelyne glycol) delivery system for the mRNA in Pfizer/Moderna. Many people already have sensitivities to this, and many more will develop such following the injection(s).
A scary set of reactions documented here: https://www.facebook.com/hilary.butler.10/posts/10160479124334018
The purpose of vaccination programs is to prevent illnesses in the individuals vaccinated but also to increase herd immunity and reduce the spread of disease.
Thanks a million times for this. Passing it on to everyone who will listen.
Can you help a layperson with terminology. I test negative for Rheum Arthritis, yet every 5 to 7 years I get dis-ease/symptoms. Do I “have” RA? I test pos. for Covid, yet have no dis-ease/symptoms. Do I “have” Covid? My antigen test is pos, yet I’ve never had dis-ease/symptoms. Have I “had” Covid.
In pre-covid-world, you were only considered to have a disease if you actually had some symptoms or signs specific for the disease. For example, you could have a positive rheumatoid factor (a blood test used in diagnosing RA) but if you don’t have any symptoms or x-ray signs of RA, then you don’t have RA. However, RA can be caused by multiple different things going wrong, so you can have a negative rheumatoid factor, but if you have symptoms and signs on X-ray suggestive of RA, then you still have RA, even though the test is negative. Since the advent of covid, people are diagnosed as having or having had covid based on a positive test, even without symptoms. So if you have a positive antibody test for covid, you are considered to have had covid, even if you never had any symptoms.
Dear Dr. Rushworth,
is there any data on seroprevalence of antibodies in the test groups of any of the studies?
In other words, would it not only make sense to test for seroprevalence to “save” the vaccine for those who could benefit from it, but also to prevent severe adverse effects? Is there any information on the reaction of vaccinees that went through an infection prior the vaccination?
Yes, I think that would make a lot of sense. From my perspective, giving the vaccine to someone who’s already had covid in the recent past is a waste. The studies excluded people with prior covid.
How do you know if you are a CovIDIOT?
1. You eagerly anticipate joining the experiment and being injected with an untested vaccine.
2. You wear a Covid diaper on your face and berate others who don’t.
3. You believe we need more, longer, and stricter lockdowns ignoring the studies that demonstrate lockdowns do not stop or even slow the spread of Covid.
Thank you very much for this great article.
mRNA vaccine are quite new and we don’t have large series of this tech being used more than a few years ago.
Do we have any reason to worry about long term safety at all? I understand there is no theoritical base for such a worry but wonder if there is not an unknown there.
As you say, there is no theoretical base for worry, but there could always be “unknown unknowns” that could cause problems, like the substance in the pandemrix vaccine that caused narcolepsy, so there needs to be careful follow-up of the people getting the new vaccines to see whether there are any signs of harm.
How many dead and how many adverse events you want before you start to worry.
The Ron Paul Institute reported this morning: ‘A Nursing Home had Zero Coronavirus Deaths. Then, It Vaccinates Residents for Coronavirus and the Deaths Begin.’ Since vaccination began 24 coronavirus-infected residents at the 300-bed nursing home have died. Is the timing just a strange coincidence? The nursing home began vaccinating residents Dec. 22.
Covid-19 vaccines have not been tested in the frail elderly, many of whom are residents of long-term care facilities. Therefore, there is NO evidence that the vaccine is safe or effective for the elderly. Jon Rappoport says, “If this doesn’t give the frail and elderly and their families pause for thought, nothing will.
Do you have a reference for this?
Are there any other situations observed of similar nature that you know of?
I really appreciate this Blog. While Seb does a truly Superior job, many of the posts are as good, and fill out the material very well. It is most helpfull.
This post points to exactly one fo the significant issues Seb brings out: the most vulnerable and most relevant patients are simply not tested, by any of the three companies he references. Effectively the relevant and mandated clinical trials have not been conducted. I find this extraordinary.
What happens when you vaccinate the people most at risk, the elderly in elderly care.
Is there anyone reading this blog who has details of the Phase IV Pharmacovigilance programs, if any, in their country? These have been mandatory since 1999. Or were. Are they still?
Clearly they are necessary and important.
Can we find them and list them?
Though Slumdog (but not a millionaire) I be, in the long long days of yore I once was a drug regulator, with, by co-incidence, initial training at the Swedish Regulatory Authorities in Uppsala. Thus I absolutely know what I am talking about, and am “Skilled in the Art” to use the formal term.
As a former (Swedish trained) drug regulator I am in awe of what has been done with the C19 vaccines. It is absolutely unacceptable, and shocking that these Marketing Authorisations have been granted on the basis of the documentation provided.
Reuters has a “fact check” of this nursing home that leaves more questions than answers: https://www.reuters.com/article/uk-factcheck-vaccine-covid-auburn-death-idUSKBN29J1NH
What we really need to determine whether the covid vaccine was a factor in these deaths is the full chronology for each death (tests and vaccinations), and the full chronology of all covid testing for all residents. Then we could make some sense of it.
* Did they vaccinate people recently recovered? This is known to be a risk factor
* Did they vaccinate people during an outbreak? The vaccine suppresses the immune system, and could cause death if exposed to SARS-Cov-2 during a post-vaccination period
Completely agree that the “testing” and “surveillance” is hopelessly inadequate. We also don’t know what will happen to vaccinated people when exposed to variants not protected against by the vaccine.
Thank you for this article. Please note that the Moderna vaccine has a higher rate of severe adverse effects than the Pfizer vaccine. Pfizer has 240 severe adverse events in the vaccine group versus 139 in the placebo group, which may be, as you state, concerning. But this concern should be even greater with the Moderna vaccine. Moderna has 2884 solicited adverse events of grade 3 (equivalent to “severe”) in the vaccine group versus 341 in the placebo group. These numbers are from table S4 of the Baden paper. Therefore, safety issues with Moderna should be an even greater concern than with Pfizer.
It is quite expected that reactivity to the Moderna vaccine, including adverse effects, is stronger, since Moderna uses a 100-microgram dose, whereas Pfizer uses a 30-microgram dose, and the composition of the two vaccines is otherwise quite similar.
As mentioned, severe adverse events are not the same thing as serious adverse events. Table S4 shows severe adverse events within seven days of getting the second vaccine dose and as you correctly state, there were 2884 in the vaccine group and only 341 in the placebo group. However, if you look as what those “severe” adverse events actually were made up of, then the number is not that concerning: 20% had pain at the injection site, 10% had a rash, 7% had a high fever, 23% had a headache, 50% experienced fatigue, 46% experienced myalgia. The grade 3 adverse events may have been “severe”, but they were self-limiting within a few days and not serious in terms of long term consequences. The reason I have a problem with Pfizers study, is because they don’t tell us what the adverse events were. Most likely the adverse events list for the Pfizer vaccine is similar to the adverse events list for the Moderna vaccine, but I’m not going to assume it, which is why I’m not personally willing to take the Pfizer vaccine until I see that data.
There is one thing that is concerning about all this though, from my perspective. The mRNA vaccines do obviously produce a lot of symptoms in the days after being vaccinated, and it’s possible that if you’re already very sick, then even these self-limiting symptoms can be enough to push you over the edge and kill you. It is therefore very unfortunate that elderly people with severe co-morbidities weren’t included in these studies, since that means there is no data on whether the vaccine is safe for them.
Regarding the ingredients in RNA vaccines. Is there shellfish in the vaccine?
Seems some people have reacted to this.
I don’t think there is any shellfish in the vaccine. But people who are allergic to one thing are more likely to be allergic to other things too.
Thanks for your response. “pre-covid-world…” since the advent of covid…” “even if even if you never had any symptoms…” I have a full head of hair, but “have” the gene for male pattern baldness: so according to my passport I’m bald? I have the engine in my car to exceed the speed limit, so I get a fine for speeding when the car is parked?
This would seem to be madness. Help me understand, what’s changed with covid?
“The party told you to reject the evidence of your eyes and ears. It was their final, most essential command”.–Orwell
Would you mind also confirming how many cells (and which cells) are targeted by the vaccines and what will the immune response be to those cells that produce the spike protein? Does it remove only the spike proteins, effectively ‘cleaning’ the cells, or does it kill the whole cell?
Simon. Grade 3’s are ‘severe’.
And we know the FDA definition:-
“Grade 3 Severe or medically significant but not immediately life- threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care ADL”
Yes, clearly these are mostly self-limiting. But if the median is 3 days, half of them persist for longer than three days!
Also, the majority of the Grade 3’s are systemic rather than local to the injection site.
In the live Moderna submission to the FDA, 9.1% local Grade 3 events were reported in the vaccine group, as were 16.5% systemic Grade 3’s in vaccine group (plus 10 in number Grade 4’s). Additionally, there are a further 1.2% unsolicited Grade 3’s. Added together that appears to mean that 26.8% of the vaccine group experienced a ‘severe’ adverse reaction.
A simple headache would not attract a Grade 3, I suggest.
The live presentation on adverse events begins at this timepoint:-
Sebastian, thanx very much for your excellent summary of the three vaccines.
Two things I want to add:
1. “Throughout the safety follow-up period to date, there has been three reports of Bell’s palsy in the vaccine group and one in the placebo group.” (Moderna, https://www.fda.gov/media/144434/download (p.45))
2. ” Bell’s palsy was reported by four vaccine participants. From Dose 1 through 1 month after Dose 2, there were three reports of Bell’s palsy in the vaccine group and none in the placebo group.” (Pfizer, https://www.fda.gov/media/144245/download (p.43))
7 : 1 !!!
good Q ….. 24 deaths within a week of injection here it seems https://www.syracuse.com/coronavirus/2021/01/covid-19-outbreak-at-auburn-nursing-home-infects-137-residents-kills-24.html
the Pfizer and Moderna vaccines both contain polyethylene glycol (PEG) as one of the lipids.
A very well know allergen. https://pubmed.ncbi.nlm.nih.gov/33011299/
And they haven’t even bothered to test people with allergies in their PMH in their studies.
I would call it at least careless …
I hope this is not silly but there seems one important aspect which has been ignored and invalidates the results of the trials!
Without the trial participants for the trial length being together all the time in the same environment (except maybe going home to sleep) their daily environments must be all different so results for the placebo and vaccine ones will all be different.
I am 81 and have not been infected and haven’t had the vaccine but if I were in a trial from several months ago and had the vaccine the result would be Oh the vaccine worked or probably had worked when that result would be the same without the vaccine.
The trial would only be valid if those with the vaccine were placed in an environment with the virus swilling around them – that would test its efficacy, no?
Perhaps I have misunderstood the methodology.
I have a question for english native speakers: Peter Doshi mentioned in his article:
“suspected cases” that were “not PCR confirmed”. What does “not confirmed” mean in this context? A negative PCR test? Or were the patients not tested?
You can find an analysis of Peter Doshi’s opinion piece here: http://hildabastian.net/index.php/covid-19/103-unpacking-doshi-take
MKJJ123: I believe it means people with symptoms and a negative PCR test. The symptoms are so variable, and PCR worthless as a diagnostic tool that the statement is essentially meaningless, in a scientific sense.
@Gary: I absolutely aggree. It was just not clear what exactly was meant by “not confirmed”. I have quite a lot discussions with a friend of mine. We are both MDs, and he is really a highly intelligent guy. However, we have a hard time talking about Corona being on opposite sites. This is a very unpleasant experience, since I thought scientific truth is the only thing that counts. But these days, even scientific truth might be debatable.
Question: Unless I’n being misled, it would appear that the three vaccines being promoted, don’t actually stop a vaccinated person from continuing to be infectious! Is this true, and if so, why? Does it have anything to do with the rush to produce the ‘Magic Bullet’, yet again, short term thinking?
Yes, I was going to ask the same question as I came down with the Bug about a month ago, so I assumed that I have immunity, at least for some months.
MKJJ123: What is truly scary is that so many Western governments have used this epidemic to become increasingly authoritarian. In the U.S. the four tech behemoths (Google, Apple, Facebook, and Twitter) now control the internet message, and have just destroyed a very popular upstart called Parler. The incoming leftist government here not only approves of this, but applauds it. Monopolies were once broken up, as they were in violation of anti-trust laws, but our Department of Justice is controlled by the oligarchs (even under Trump), so I’m not hopeful. Life is looking bleak for freedom.
@Gary: I absolutely aggree. It is a nightmare.
barovsky: The protocol called only for a difference in numbers between treatment and control groups in symptoms, with PCR confirmation, and nothing else. Nothing about transmission; nothing about severity; nothing about children, pregnant women or nursing mothers; almost nothing about the frail elderly. And the followup period was only two months. Two months! This is not science. By the way, it’s good to hear from you.
Well I’m 75 and although I’ve got stents in my heart, I think my immune system is in good shape (is this a paradox?). In any case I came down with the Bug about a month ago,and initially, my only symptoms being loss of taste and smell. A few days later, I felt unwell and thinking it was my heart, went to A&E where they informed me that my heart was fine and following a (PCR?) test, blood tests and an x-ray, I was informed that I had bacterial pneumonia in my left lung. I was given 5 days-worth of penicillin and sent home. I seem to have recovered, though my sense of taste isn’t what it used to be.
Did I get the bug? I have no idea. I don’t know what test they used but I assume the PCR, or how many cycles it went through, neither did I see the x-ray.
The hospital confirmed that I had SARS-COV-2, so I suppose I have to take their word for it.
Howzit Gary! For some reason, I’m unable to post to Kendrick’s blog, I think I have an old, duplicate WordPress account screwing things up, but as you can see, after getting the bug I’m still alive and kicking!
I have family who have said one of the main reasons she would not get the vaccination is that the technology was build through the benefit of stem cells derived from aborted fetuses. So this has become an ethical decision rather than a medical. Can you enlighten me on the veracity of this claim? I have no opinion either way; I just want to know the truth, so that my conscience can contribute to my decision making process.
Barovsky: The same thing happened to me for about two months (and to Bill in Oz last Spring). But one day the comments started posting again, so keep trying! We owe an enormous debt of gratitude to Dr. Kendrick for helping educate all of us. Good to know you’re doing well. I’m doing better than ever thanks to the Carnivore Diet. Give it a try (“The Carnivore Code,” by Paul Saladine, M.D\.
Carolyn Vaughn: Yes, there are fetal cell lines used in medical research and vaccines (how they’ve immortalized them I don’t know; there must be some sort of biological switch in fetal development which stops cell division). At least one of these three vaccines uses them.
This, concerning the possibility of transmission by the vaccinated:
Thank you Sebastian.
I think the conclusion is that for any healthy person below 70 it is not only safer but achieving longer lasting immunity to get naturally infected than taking the risk of the vaccination.
Now, the challenge is to find someone in Australia to get infected from.
I don’t get it! This from the link you provided:
““These COVID vaccines are preventing clinical disease, we don’t know if they prevent transmission [of the SARS-CoV-2 virus],” says infectious disease expert Chris Beyrer, MD of the Johns Hopkins University Bloomberg School of Public Health. According to vaccines expert David Diemert, MD of George Washington University, it is not known if the COVID-19 vaccines will prevent the SARS-CoV-2 virus from entering the body or leaving a vaccinated body.”
I don’t get it. If you’re vaccinated AGAINST the virus, it seems that one of two things has happened:
1. The vaccine prevents you from contracting the disease because the immune system has been ‘primed’ by the vaccine to eradicates the virus, hence there’s nothing to infect anyone with;
2. The vaccine prevents you from the SYMPTOMS of the disease but doesn’t remove the virus from the body, which means that it’s not truly a vaccine but some kind of preventive medicine. Thus you’re not ‘sick’ but you might as well be, because you’re just as infectious (or not) as someone who hasn’t been .vaccinated’.
What is going on here? It seems that Boris Johnson’s ‘we’re guided by the science’, has very little to do with real science.
thanks for your work and your valuable neutral analysis!
I would like to highlight one very, very important aspect with respect to the vaccines. For all three vaccines the pre-clinical trials have been skipped entirely. There is no data at all! The vaccines went straight away to phase 1, 2, 3.
That is one extraordinary important aspect which I would like you to add to your article.
Thanks and best regards
barovsky: yes, it is option 2. I suspect an intramuscular vaccine will only make your body produce IgG antibodies, which are the ones that neutralize the viruses when they get into your body. So if you have them, you may get minimal symptoms when you contract the virus. But you will contract it.
Among of what you need to stop contracting and spreading the virus are the IgA antibodies, present in your mucosa cell surface, like your nose and throat. These are minimally generated by an intramuscular vaccine.
There was an experiment with influenza where they gave mice a vaccine either intramuscular or intranasaly. The intramuscular reduced spread of the disease by 88.2%, while intramuscular only by 47%.
So it’s likely that the covid vaccine won’t really stop the spreading. But maybe you develop IgA antibodies after you contract the virus after you take the vaccine, and (hopefully) experience only minimal symptoms.
The best way to prevent transmission is to really contract the virus, so your body will produce all the different types of antibodies.
Thanks for this, it’s as I suspected! BTW, I caught the bug about a month ago and aside from some hangover effects (fatigue, stomach problems from the penicillin), I seem to be okay, so as Dr Rushworth says, I don’t need the ‘vaccine’ (can they really be called vaccines?).
Otto, I think your logic here is entirely sound. But how you get tens of thousands of volunteers in the same environment sounds like a logistical impossibility!!
Re not being vaccinated if you have already contracted the virus, see:
“Mevorach told Channel 12: “We found out that the young man had contracted the coronavirus asymptomatically before he was vaccinated. It may be accidental but I would not underestimate it. Care must be taken in vaccination of people who were sick with coronavirus in the past.””
PS: Lex, are you sure about your understanding, that it is Option 2? This is extremely worrying if true, does it mean people will have to be ‘vaccinated’ regularly?
“As with the previous two trials, the primary objective of the study was to see if there was a reduction in cases of covid-19, which in this study was defined as at least two symptoms suggestive of covid-19 plus a positive covid PCR test.”
So, here they need ADDITIONAL TWO SYMPTOMS to call a person infected, while in the mainstream you are infected as soon as your PCR test comes out positive. I’d say that is laughable, as you then will have a lot less positive cases, which then allegedly proves that the vaccine is working in a positive way.
Change of criteria, and voila, the vaccine works 🙂 Does this virus even exist? What happened to the seasonal flu-cases?
Can you speak to this?
I’m not a scientist, but I think I understand how vaccines work and have an idea of how the immune system works but how do I assess whether this Cahill video is accurate, ie factual and not just Cahill’s opinion? And it’s this that’s at the heart of the confusion and hence fear, with everyone becoming epidemiologists, statesticians etc, because we’re bombarded with so-called fscts!
Thanks for this useful analysis- I assumed Moderna was the best because that is the one Fauci received!
Also, please provide another Sweden update when you have the chance.
Adam Orkand: The vaccine being produced by Moderna was actually developed by scientists being paid with my tax money. Yes, Fauci’s crew at NAIAD. Moderna is a biotech company which had never successfully brought a product to market, and were close to bankruptcy until Fauci rescued them. Those government scientists who own the patent for the vaccine, along with the U.S. government, will now be each paid $150,000 per year in royalties after Fauci sold Moderna the licensing rights. A real growth industry, vaccines. To a stockbroker, it’s a buy!
Scary reports of serious injuries. https://www.facebook.com/YoDaSaNgEr/posts/851866608929963
Collection of injury reports at https://hpv-vaccine-side-effects.com/covid-19-vaccine-side-effects-world-map/
And this is just the first dose, after people are sensitized to the PEG it will get worse.
Another sad story from the COVID vaccine. https://www.facebook.com/brant.griner.7/posts/900291600708120
Thanks for yet another great analysis of the pandemic. I do wonder, however, what you make of the claims of BMJ editor, Peter Doshi. Doshi has questioned the data for all the vaccines, pointing to questionable practices in testing for minor symptoms of covid in both the vaccine and control groups. If he is correct, this would dramatically lower the efficacy of these vaccines.
His most recent analysis is here (BMJ, ‘Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—we need more details and the raw data’, January 4, 2021): https://blogs-bmj-com.ezproxy.princeton.edu/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/
If you can’t access the BMJ piece, there is a slightly different version here: https://childrenshealthdefense.org/defender/pfizer-moderna-need-more-data-claims-effective-vaccines/
Thanks and keep up the great work!
Interesting, how the definition of herd immunity by the WHO has changed over the last few months:
SalkiN: Thanks. The June and December statements seem to be essentially the same, but in November they removed the actual definition of herd immunity, that which occurs during outbreaks of natural infection.
Dr. Rushworth said:
Actually it seems narcolepsy risk was elevated even the second year after vaccination. As stated by Granath et alter (2019):
I don’t know in the SARS-CoV-2 case but vaccines trials are given an almost free pass in respect to identifying adverse events outside the first month, as exposed by Frederik Joelving in the GARDASIL case.
Not knowing which are going to be the long term effects of these vaccines if any, I don’t think they are justified outside high risk groups.
Hi Gary Ogden,
the December version is all about vaccination. Vaccination. Vaccination. Vaccination.
Very curious is the last sentence:
“Achieving herd immunity with safe and effective vaccines makes diseases rarer and saves lives.”
With an vaccine, which is approved under Emergency Use Authorization (EUA)?
Why should the healthy non-risk ones be vaccinated, though it isn’t even clear – by any means – if he/she can spread the virus afterwards as well? And the healthy non-risk ones usually don’t get very sick with this virus.
An how on earth can’t we be “exposed” to a virus? By lockdowns, social distancing and masquerade forever?
It all doen’t make sense, though …
Thank you for a very interesting article. You say the astra zeneca study was based in UK, South Africa and Brazil. Is that just a coincidence that the more virulent strains mentioned by MSM are from those same countries?
Dear Dr Rushworth, I’d like you to expand your comment, if possible, on the inadvisability of getting vaccinated, if one has already caught the virus, as I’m one of those people.
I can’t really see what the point would be in getting vaccinated if you’ve had the infection. The real infection is much more likely to generate effective lasting immunity than the vaccine is, because real infection leads to creation of different types of antibodies, while the vaccine only leads to creation of IgG, and because real infection leads to the development of adaptive immunity against multiple viral proteins, while the vaccine only leads to immunity against the spike protein.
Thank you, it confirms what I already suspected. Now, how to convince my GP here in the UK!
4/ This is nearly all the first dose, and the second dose has side effects at 3-10x the first. And this is mainly the
shot has more side effects.
Not even as a booster? Effective immunity from Covid may be declining with time.
For me the best solution to end these boring conversations surrounding jabs and safety is the following:
In all vaccines studies the trials are done using the people that are working directly in the developing and production process of the new jab and if these are not enough they can use the other people that work in that corporation.
If the trials are successful WE ALL KNOW that that vaccine is indeed safe because those that developed it put Their Skin in the Game!
If the trials are unsuccessful and some or all of them have serious health problems and/or die WE ALL KNOW that that vaccine is not SAFE FOR US. A bonus part is that these failed developers won’t waste anymore resources anymore.
Until this is implemented the JAB CIRCUS will exist forever and ever!
Thank you for your well considered article, Dr Rushworth. You consider yourself young and fit enough not to need to take the risk of being vaccinated, but what is “young” enough! I’m 60; have only been ill and hospitalized once with community acquired pneumonia (and sepsis) in May 2019; have no other diseases and am not obese; but do have an allergy (rash all over) to Metronidazole. Could someone in my age and fitness bracket be considered young enough not to need to take the risk of having one of these vaccines? Your thoughts would be much appreciated.
I can only speak for myself. I’m 37 years old, have no health issues, am physically fit, eat healthily, and make sure I get enough vitamin D and other nutrients, so I think the risk to me personally is infinitesimal. Additionally, I’ve been working closely with covid patients all year, so I figure that if I was going to get covid I would have gotten it by now. I can’t tell you what’s right for you, all I can do is provide the information that is available from the studies. Some people do get seriously ill from covid, and the vaccines do appear to decrease that risk by a lot, so you really have to weigh the potential risks against the potential benefits for yourself on an individual level.
Have you seen the video below by Dr. Simone Gold? I’d be very interested in your opinion. Are her concerns correct?
Crikey, just watched this video which also features Robert Kennedy Jr., Michael Yeadon, Dolores Cahill and others…and on the other side…Bill Gates, Klaus Schwab, Prince Charles…
And what about ‘our elected politicians’ who have bought into this caper and sold us down the river…? Boris Johnson, Matt Hancock, Joe Biden, Justin Trudeau and co…
This documentary sums it all up – self-styled ‘elites’ are planning to displace humanity with AI. Welcome to the ‘useless class’ of ‘hackable animals’…
The people behind this are traitors to humanity…
The New Normal Documentary by happen.network:
Thought about ending it all but the end did provide a glimmer of hope. Thanks for the video.
Probably, you know that 40% of infected people don’t develop antibodies? May be you belong to this group? Eg
Thx for your work and this article! Joerg
thanks for giving a summary and an overview about the new vaccines.
How do you assess mid- to long-term risks of ADE-events (as reported for exampled on Dengue or FIPV in cats) as the new vaccines aim at only one epitope of the S-spike protein in the absence of TLR, which probably does not “simulate” a regular immuno-response ?
What do you think about the risks of using PEG for encapsulating the vaccine (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817614/) ?
From my point of view, these are both risks that are probably not yet assessed and will be obvious only over the next years.
As you say, it will be at least a few years before any potential long terms risks can be assessed, so I can’t really comment.
What long-term side effects of vaccines are known? At what point would you state that we have waited long enough?
“At a virtual press conference held by the WHO Dec. 28, 2020, officials warned there is no guarantee that COVID-19 vaccines will prevent people from being infected with the SARS-CoV-2 virus and transmitting it to other people.”
So is this a real vaccine? It seems not, yet millions are being produced and injected into millions of people! Surely, this is madness?
barovsky: A completely unnecessary vaccine which is also completely worthless except at injuring and killing people. Along with the most massive transfer of wealth in human history from the 99.99% to the 0.001%. Do not submit, folks. Get the boot off your neck!
It doesn’t say that! Using the highly unreliable RT-PCR ‘test’ it says there MIGHT be reinfection but the sample was so small that generalisations can’t be reached. It’s typical of the kind of ‘scientific’ articles being written that end up being nothing more than opinions.
Gary, worse still, the bloody things don’t do what they say on the label! Maybe they can be sued under the Trades Description Act?
How can they call this a vaccine?
“Vaccine means a specially prepared antigen administered to a person for the purpose of providing immunity.”
The only immunity these “vaccines” have is against law suits
My fear is about the ‘enhancement’ that you might have described previously or I read elsewhere. That’s why a corona vaccine was never made before although they’ve been trying since 2003. All or most of the test animals died in those attempts because a wild virus caused a cytokine storm. Can you comment on this please. This wouldn’t show up in the clinical trials, more than likely they would after a longer time period.
they would never include the frail, elderly for exactly what might happen to them. They might die! They certainly would have a much greater chance of that than any other group. It wouldn’t be a good look, would it?
Joe Biden was just inaugurated today, so I don’t think he has done much of anything yet. But your hero, Donald trump did actually put everything in place for JB to step in.
Well said. Thanks for posting.
Hi, interested to know why you think it is likely that they do reduce transmissibility?
Because after you have immunity, your immune system will generally discover and suppress infections more quickly.
It’s possible that’s wrong though – the vaccines probably only induce production of IgG, not production of IgA, which is the type of antibody found primarily in the respiratory tract, so having gone through real infection is likely to decrease transmissibility more than just having been vaccinated.
So the start of A Handmaidens Tale then?
Dr Rushworth, I’m confused. If the mRNA version doesn’t confer immunity nor stop you being infectious, how can it be called a vaccine? It sounds like the ‘vaccine’ is, in reality, just a money-making machine, as for it to be really effective, EVERYONE on the planet will need to be ‘innoculated’. A license to print money?
Immunity doesn’t mean you can’t be re-infected. It just means that you’re immune system responds much more quickly when you do get re-infected, so most likely you won’t even notice that you’ve been re-infected. As to the other thing, we don’t know that the vaccines prevent transmission, because that hasn’t been studied. But most likely they do at least somewhat decrease how infectious you are, and for how long you are infectious, by causing the immune system to react more quickly to the virus when you do get infected, and thereby reducing production of new viral particles more quickly.
I agree that there is a lot we still don’t know about the vaccines, and that they’ve been rolled out on a massive scale before we have enough information to truly say that they are safe and effective, especially for those who are most at risk of severe disease.
I still don’t get it. Earlier on, you spoke about the ‘fact’ that the mRNA ‘vaccine’ doesn’t ‘provoke’ the immune system but modifies the ‘spike’ on the protein, which in turn, ameliorates the effect of the virus, thus you can still get infected but without the severe symptoms. Okay, the jury is out on whether an ‘innoculated’ person can still be infectious but it’s seems that the ‘vaccine’ DOESN”T protect you from contracting the virus, so how can it be called a vaccine?
No, that’s not what I said. I said that the mRNA vaccine basically injects the mRNA that codes for the spike protein in to the cell. This causes the cell to produce the spike protein for a short while, and express it on its surface, which results in activation of the immune system.
If the definition of a vaccine/immunity were that you could not be infected, then according to that definition there are no vaccines and no-one is immune to anything. The cells in your respiratory tract that get infected by sars-cov-2 are still there, and haven’t changed at all, so they can still become infected. The difference is that you now have T-cells and B-cells primed to react to the virus, and so you get a much quicker immune response after infection. Sorry if that hasn’t been clear earlier.
barovsky and Sebastian, what do you think about this explanation from Dr David Martin?
Okay, I think I get it. You say:
“The difference is that you now have T-cells and B-cells primed to react to the virus, and so you get a much quicker immune response after infection.”
I assume this is after getting vaccinated? But how does this compare to getting infected and the immune system kicking in and producing antibodies/T Cells/B cells etc?
Most likely, infection induces a much broader and more robust immune response than vaccination, because real infection results in immunity against multiple viral antigens, not just against the spike protein, and results in multiple different antibody types being produced, not just IgG. There are examples of vaccines that produce better immunity than real infection, but usually real infection produces better immunity than a vaccine.
Would you recommend getting the a vaccine if you were a healthy woman and wanted to have children in the near future?
Considering that women attempting to get pregnant and pregnant women were excluded from the studies, there is at present no data that shows that the vaccine is safe for this group. If it were me, I would want to wait until more data is available, especially since the risk from the virus to a young healthy person is infinitesimal.
So we don’t know if the vaccine stops transmission, because that hasn’t been studied. We don’t know if it is safe for a pregnant women or women wanting to get pregnant because that hasn’t been studied.
To legally fast track a “vaccine” there must be no safe alternative. Perhaps that is why they’ve trashed the hydroxychloroquine protocol and Ivermectin. Both cheap drugs.
Too many unknowns for me.
What is going on in the UK?!?!
According to EUROMOMO, England is experiencing extraordinary high excess deaths.
Wales has low excess. Scotland has moderate excess. And Northern Ireland has no excess.
So what is going on in England?
See: Week 01, 2021: https://www.euromomo.eu/graphs-and-maps
Rondo, you say “To legally fast track a “vaccine” there must be no safe alternative. Perhaps that is why they’ve trashed the hydroxychloroquine protocol and Ivermectin. Both cheap drugs.”
Wow, if they’ve suppressed drugs to facilitate the fast-tracking of experimental vaccine products…how bad is that?!?!?
Plus the reluctance to promote vitamin D.
We’re seeing a crime against humanity in progress…
We don’t seem to know if the experimental vaccine is safe for elderly or those with preconditions or suppressed immune systems or auto immune diseases because the studies are done on young, healthy individuals.
elizabethhart: Indeed we are. A crime against humanity, especially in regard to the children. Will the perpetrators ever face the consequences? I rather doubt it. Yet, the public in the U.S.szshas become increasingly skeptical. We’ve just lost one of our most gifted athletes, a real gentleman and icon of baseball, Hank Aaron, to the ‘Ronavax. One of those publicity stunts gone wrong. Black Americans are rightly skeptical of official government medical treatment because of Tuskegee. A completely unnecessary and dangerous vaccine whose only purpose is profit.
Gary, where are you, in the US or UK or elsewhere?
I’m gobsmacked at the way in which so many people are meekly taking this totalitarian rule, what on earth is the matter with people? Have they no critical faculties whatsoever? Or is it that so many have been bought off with comfortable furlough?
Others of course are just plain terrified by the blatant misinformation/propaganda pouring forth from the media, all the fearmongering and alarmism.
And of course ‘the authorities’ seem to be doing all they can to make the consequences of the virus worse, by rejecting or playing down treatments and promising preventatives such as vitamin D…all to facilitate the fast-tracked experimental lucrative vaccine products it seems…
‘The authorities’ are actually making people more susceptible to illness, by locking them down, muzzling people with highly questionable and potentially harmful masks, inhibiting family and social networks, inhibiting exercise, creating anxiety, promoting OCD behaviour via over the top handwashing etc.
They couldn’t have handled this worse if they tried…but maybe they are trying?
What a global disaster. And all courtesy of ‘our elected representatives’, apparently the puppets of the WEF and co, and the ‘scientific establishment’ and vaccine industry.
So, no adverse effects from the vaccine eh?
Elizabehthart: I’m in the U.S., in California, one of the states run by a hypocritical tyrant. Not nearly as bad here as in the UK or what we heard about Victoria, though. I’ve maintained a completely normal life during this nonsense except having to shift my shopping to a neighboring city which is run by intelligent people, and cancelling medical appointments because I refuse to wear the face diaper. I maintain my sunny disposition, but what deeply concerns me are the multitudes of sheep lining up for this experimental medical product. Do they know the clinical trials are not yet finished? That they are liability-free? That safety and efficacy data come from only two months followup? Likely no, no, and no. This is a disaster in the making, and it will unfold relatively slowly, as the rate of adverse effects will not be known for months or years after mass jabbing. And now we have a fake president, along with a worthless Congress, who is appointing worse swamp creatures than even Trump found. An ill wind blows, but I retain my joy in living!
I too live in California and would move in a minute if my sons were not living nearby. I agree with you 100% about your expressed sentiments and have decided that in 2021 I will get the ultimate revenge by (1) remembering everything, especially all the insults, threats and accusations thrown at me but (2) exacting revenge by living a very joyous life filled with awe and gratitude to G0d for all my blessings. So many activities used to be fun such as going out for coffee. Now everything has become a chore worthy of Soviet style life. I will wait on the experimental vaccine for now until they results are in on those who most need protection. So far it seems the studies are on those who do not need protection and are most likely to survive with no more than flu-like or no symptoms at all. Also, I will NOT take the vaccine until I have a reliable test that lets me know if I have already been exposed to the virus. I believe I may have had it in February-March but nobody here in CA will point me to a test to see if I have immunity. P,S. Have you signed the recall petition?
wanted to show their vaccines worked in the population that is actually at meaningful risk from #SARSCoV2, doing so would have been simple. They could have enrolled patients at nursing homes – JUST AS
DID with its monoclonal antibodies…
Not ALL elected representatives but definitely ALL in one major party and SOME in the other.
Flayeri: Yes. Last I heard it had 1.1 million signatures, with 1.5 million needed by March. Worst governor in my lifetime.
What do you think about this?
Steve Hilton (Fox News) blows Fauci out the Universe with GAIN OF FUNCTION EXPOSE
I appreciate your open mind and rational comments
Could you comment on this?
Its it not worrying that people are being vaccinated before trials are over? It feels like the people taking the vaccine now are being used as guinea pigs for stage 3 of the trials..
says pregnant women should NOT take the vaccine (with a weird exception for health-care workers:
“The use of this vaccine in pregnant women is currently not recommended unless they are at risk of high exposure (e.g. health workers).”
Thank you for such a detailed and easy to understand report.
Can I assume that none of the trials involved anyone with cancer?
I have been offered a vaccine but have recently had surgery for recurrence of breast cancer and will be taking hormone blocking drugs, but no chemo or radiation this time.
I feel that the vaccine would be overload for my immune system at the moment and there seems to be no clear data on safety in this situation. So am thinking that I would be wise to wait.
Any thoughts or information about the vaccine for people with cancer would be gratefully received.
You are correct that people with cancer have to a large extent been excluded from the studies.
Jules: In clinical trials for both drugs and vaccines, the exclusion criteria generally make the trial cohort the healthiest of the healthy, but they are then licensed for the general population. This is why all trials have a Phase IV component, after-marketing surveillance. The problem with vaccines are two-fold: 1. They are liability free; and 2. The surveillance system is broken (at least in the U.S.).
If you want to make sure T-Detect in Washington State has a test now that is very good for T cells.
Thank you so much, David! Does anyone here have any experience with T-cell testing for Covid?
Dr Simone Gold
As I understand it from your comments above and articles elsewhere regarding the effect of the vaccine on likelihood of transmission, the vaccine studies provide no basis for thinking that the vaccine in and of itself will be a means to achieve herd immunity. Rather, we can say that they may, where safe, reduce the cost, in terms of severity of symptoms, of achieving herd immunity the old-fashioned way. As a result, I assume another important implication is that we have no basis for arguing that the vaccine provides a benefit to anyone other than the recipient.
David S.: Nor can we have confidence that it even provides benefits to the recipients. No trial is yet complete, and no raw data has been published. The followup period is now only about three months, much too short to see danger signals. These medical products are nothing more than a highly profitable risky experiment on an unwitting public for a condition which is only dangerous in the frail elderly, and is easily and successfully treatable by at least three long-licensed drugs with good safety profiles: HCQ, ivermectin, and budenoside. The public is participating in phase III of the trials. In other words these “vaccines” are completely unnecessary. But the media has whipped up hysteria, and governments have responded in their typical bumbling ways.
More than 40 articles on IVM and over a hundred on HCQ besides “Real World Evidence” uses all over the world show that anyone can use pharmacological prevention and early out-of-hospital treatment with safe and cheap drugs that would reduce immensely the need for hospital intervention. Anyone who knows it can safely skip vaccines. Countries that use it have much lower deaths per million than the US, de EU countries and UK, among others. Check, for example India, China, South Korea, Costa Rica, Turkey, Senegal, etc.
Excellent meta-analysis at https://ivmmeta.com/ and https://hcqmeta.com/
Well actually, I was treated with two kinds of penicllin, as I was being treated for bacterial pneumonia, caused I assume, by the virus, so every case seems to be different.
Experiences with the vaccine.
“There will be, in the next generation or so, a pharmacological method of making people love their servitude, and producing dictatorship without tears, so to speak, producing a kind of painless concentration camp for entire societies, so that people will in fact have their liberties taken away from them, but will rather enjoy it, because they will be distracted from any desire to rebel by propaganda or brainwashing, or brainwashing enhanced by pharmacological methods. And this seems to be the final revolution”
― Aldous Huxley
J n J looks like the safer and better vaccine
COVID Vaccines, Masks and Schools, with Alex Berenson and Dr. Jay Bhattacharya
You mention that there were three arms to the Astra-Zeneca trial, in the UK, Brazil and SA. We’re now seeing new strains of the virus originating in those very three countries. Could there be a link? Thank you.
Hi, yes. I would like to know the long term affects of these vaccines, nobody can possibly tell yet. For example, what happens if the vaccinated are later exposed to a wild form of the virus or indeed, any other virus? I have heard there are risks of cytokine storms?
The trial results rely on the positive or otherwise result of a covid test after vaccination. But what if the covid tests themselves are unreliable, which I have read often times, they are? What if those that tested positive after vaccination simply had a cold, or maybe flu? The symptoms can be similar. I echo what others have said on here…..why the grand push for a global vaccination when the recovery rates without treatment, are so high for the vast majority, and when there are other cheaper possibly safer alternative treatments available?
In UK, they merged the flu stats with the covid states around mid 2020. Why would they do that?
If you have already had covid-19, and recovered well from it, why would you need the vaccine?
Overall mortality in nursing homes is up dramatically post-vaccine.
Sebastian, thank you for your article. Can you comment on the safety of the Coronavac/Sinovac vaccines as well?
The trials have been unblinded and those given placebo have been offered the vaccines. This despite continuing the studies for two years being a condition of emergency use autorisation.
That is absolutely unbelievable. That means we’ll only ever have two months worth of randomized data on safety and efficacy.
This might be why Dr Ron Brown calculate the ARR to to be barely 1% whereas you have found it to be 95%?
Sebastian, I wonder what your thoughts are on the J&J and Novovax vaccines. My understanding is that these are vaccines in the sense that we normally understand and do not use new and experimental technology. I am loathe to be forced into having any unnecessary medical procedure but it looks increasingly like I am going to have to if I want any kind of meaningful life and so am inclined to take one of these.
I’ll just leave this here …
There are over 2000 recorded deaths in the US and Europe after administering the vaccine. Since the vaccine is not a live virus what is the cause of death?
On a related note, as all deaths after being tested positive for Covid are counted as Covid deaths, shouldn’t all deaths after administering the vaccine be counted as vaccine deaths?
Andre Socha: Yes, they should be, but they won’t be. It may not be true of Sweden, but the U.S. government, the UK government, the WHO and the EU work, not for the health of the public, but for the medical industry. The deaths after these vaccines are indeed alarming, but I suspect the true impact will unfold over time, as the immune-enhancement effects of them (at least the mRNA ones, Pfizer and Moderna) will affect a more significant percentage of the population. The phase 2/3 trials now have only 3-4 months followup data. In the U.S. there is still no system set up to monitor adverse events. In the mightiest country in the World. This is intentional.
Dr Rushworth –
Have you had a chance to read the Lancets publication on the Sputnik vaccine and do you have a similar type
Of analysis on it that you would be able to share?
Here’s info on the reason why I won’t get vaccinated:
In this video interview, Dr. Hooman Noorchashm, surgeon and patient safety advocate, explains why he’s written a second letter to the FDA urging the agency to require pre-screening for SARS-CoV-2 viral proteins in order to reduce COVID vaccine injuries and deaths.
If you’ve already had the virus, then the vaccine can provoke an over-the-top immune response.
Opinions on this anyone? The NHS are claiming that not only might I catch it again but that I might still be carrying the virus (though it offers no evidence of either). The NHS cites a study of 8,000 or so, with 32 “probables” and 2 “possibles” reinfections but no actuals! I have no info on the infectious assertion but again the wording is basically it might be the case but there’s no info on how likely it might be the case. I get the feeling the govt and its minions are fudging all the numbers and just bombarding us with unproven assertions but because it’s ‘official’, people believe it.
Sebastian, are you aware of the open letter that Geert vanden Bossche wrote to the WHO about the danger vaccination during a pandemic may lead to? It’s frightening and I’d like experts to review this: https://dryburgh.com/wp-content/uploads/2021/03/Geert_Vanden_Bossche_Open_Letter_WHO_March_6_2021.pdf
yes me too please
An eye-opening investigation with a cell biologist especially about the unresolved security issues with mRNA technology in the Pfizer vaccine: http://enformtk.u-aizu.ac.jp/howard/gcep_dr_vanessa_schmidt_krueger/
Great stuff here. You interpret the ARR as 95% for Pfizer. Why does Dr Ron Brown say it’s barely 1%?
Thanks for any guidance!
95% is the relative risk reduction. 1% is the absolute risk reduction. When it comes to the vaccines, I think the relative risk reduction is the better number to focus on, since only around 1% of the people in the studies actually got covid, so the absolute reduction they could show at best is 1%. But in the real world, we assume that around 70% of people will eventually have to develop immunity one way or another before herd immunity is reached. So, if the studies ran long enough, we would actually expect to see a 66.5% absolute risk reduction (70% x 95%), assuming there was no prior immunity. As you can see, focusing on absolute risk reduction in this instance grossly underestimates how effective the vaccines are, which is why I think relative risk reduction is the better measure to look at in this particular situation.
Thank you so much, that’s very informative. What would you speculate to be the motivation for Dr Brown’s focus on the absolute risk reduction?
But we can’t assume no prior immunity!
And (for the Pfizer phase 3 trial) with the FDA uncovering “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 in the vaccine group vs. 1816 in the placebo group”, that 95% is looking horrendously overstated. Not to mention begging the question why weren’t these 3410 people with symptoms tested? Isn’t that what the trial is supposed to do?
This may be a stupid question but do any of the Covid vaccines effect women’s fertility? I’ve heard conflicting things. Is it safe to take if you want children in the future?
I know of a couple of people who a week or so after receiving the vaccine were in the hospital with bacterial pneumonia. It is common knowledge that secondary bacterial infections in the lungs after a bacterial infection are common, and from what little I could find this is because the immune response contributes to this. Have you heard anything else about this? Could the immune response to the vaccine be the cause of this? “One major complication of viral infections, especially pulmonary viruses, is colonization of the viral affected organs by bacteria which is associated with high morbidity and mortality rates (Figure 1A), following a weakened immune response and/or opportunistic and accessible routes of entry for bacterial pathogen(s)” https://www.frontiersin.org/articles/10.3389/fmed.2020.00420/full
Metzger and Keer Sun, PhD, of Albany Medical College, conducted research in mice suggesting that interferon-gamma produced during T-cell responses to influenza infection can have an inhibitory effect on bacterial clearance from the lung by alveolar macrophages.
“This suppression of phagocytosis correlates with lung [interferon-gamma] abundance, but not viral burden, and leads to enhanced susceptibility to secondary pneumococcal infection,” https://www.healio.com/news/pediatrics/20120509/secondary-bacterial-infections-common-with-viruses
Very helpful article. Thank you. I’m curious as to the potential for long term impacts of the MRNA vaccines. I just finished reading a long technical research paper on this topic which suggests a number of potentially serious risks that could eventuate in months or years of getting a vaccine and be compounded by booster shots.
Can you comment on this?
My understanding is that while the relative risk reduction for the Pfizer and Moderna vaccines is roughly 95%, the clinically relevant absolute risk reduction for Pfizer is only 0.7% and 1.1% for Moderna. I would like to know why you chose not to mention this critically important fact. It is hard to believe that the majority of ethically informed people would elect to be injected with an mRNA vaccine authorized for emergency use that only reduces symptoms and has absolutely no long term safety data for a virus that resulted in only a 0.5% all cause mortality increase in Sweden for 2020, and an infection fatality rate that is only slightly higher than influenza for those age 70 and above. I am convinced that the majority of providers inoculating their patients with these vaccines are ignorant of the difference between relative risk and absolute risk.
Because I think relative risk is closer to the truth in this instance. The follow-up period here was only two months and only a few percent of the study populations were exposed to the virus. But most experts don’t think the pandemic will end until 70%+ have developed immunity. This means that absolute risk will in this case grossly underestimate the real risk reduction. If the studies had gone for two years before presenting results instead of two months, the absolute risk reduction would have been many times bigger, but the relative risk reduction would likely be roughly the same. While relative risk often overestimates benefit, absolute risk often underestimates it, and in this particular case relative risk is much closer to the truth.
Isn’t it a bit simplistic to rely on such measures anyway? They’re only sketchy proxies which are also contingent on full and honest reporting … which we know only too well we can no longer rely on from most major pharmaceutical companies. Peter Doshi’s article here (https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/) is pertinent. We still haven’t heard what happened to the “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population” … Why weren’t they even tested if part of a trial?!!
What I’m seeing in the UK amongst friends and family is that far more people appear to know someone who’s died or been seriously harmed by these experimental treatments than has died or suffered serious consequences from CoViD. This appears to be widespread, while many in the medical profession seem up to their eyeballs in cognitive dissonance. If the ‘cure’ causes more harm than the ‘disease’, then we have a serious problem on our hands.
Yes, I’ve had the same experience, knowing more people injured by the vaccine than from covid. I know one person with convulsions, another with a heart attack, and no one who had a serious covid illness. We are also not testing/tracking for overall neurologic affects, but they seem to be common (blood clots in the brain, presumably).
I’m also quite concerned about medium- and long-term risks from all of the covid vaccines. We will see, but no one knows what the results will be.
How can vaccine effectiveness be determined without proper contamination to sars-cov-2 (will be deemed unethical, of course) and simply by letting participants ‘loose’ without controlling behavior?
This is really an excellent analysis. Thank you so much for your time and effort.
There is something I’ve been very curious about for a long time, but I don’t have the ability to determine by myself (I guess it’s ultimately indeterminable anyway?):
Is it possible that the extreme scare-mongering that has been ongoing since the beginning of this pandemic has had a strong nocebo effect on many people who were infected with Covid? I.e., could many people have died simply because they were convinced that getting the virus would be a death sentence?
Essential watch about adverse events and deaths from the vaccines in the U.S.
“Overall, the Moderna vaccine does appear to be both effective and safe. Would I be willing to take it? Yes, I would, actually. ”
Did you took the Moderna vaccine ?
It’s now early July here in Sweden and as a 33 year old healthy individual I’m now offered the vaccine. I’ve had the infection (dec 2020) and personally taking the vaccine doesn’t make any sense for me. My question is if I’m being selfish not taking it? Close friends went hysterical when I said I wasn’t convinced taking it. What’s your take on this? In Sweden it feels like you’re expected to take it regardless of age, health etc.
For someone who has had covid there is no reason to take the vaccine. It’s been shown in a recent US study that people who have had covid and then been vaccinated do not have better protection than people who have had covid and not been vaccinated.
How do rates of reinfection compare to breakthrough cases (in severity and rate)?
I understand that you have questions. My question is how do we get the answers? What are you waiting for in order to answer you questions? Have the results of the vaccine rollout provided any answers or more questions?
Is there an age at which you recommend taking the vaccine? How is this affected by the (current) low infection rates? Would your recommendation change for a different variant?
For a hypothetical ’33-year-old healthy individual’ what do you calculate as more ‘fatal’ – infection or vaccination?
Into the numbers you seek you should also ask not just about fatalities from the jab but the chance of serious injuries. The way I’m looking at it is what are the chances that (1) I’ve already been exposed to Covid-19; (20) have already developed some amount of immunity; (3) may still contract Covid-19; (4) become the small percent who become hospitalized from the disease; (5) die from it. All those conditions must be assessed before I decide to add an experimental genetic therapy into my system. It seems I cannot ask any physician for the information I seek to help me make up my mind: (1) do I have the T-cell immunity from a prior infection or the “flu” I had at the beginning of 2020; (2) what is my risk that the jab may exacerbate some previous conditions I had; and (3) I’m currently on an anti-viral medication and does that anti-viral provide me with some protection from the corona virus. NONE of my current corporate physicians can answer my questions or if they have opinions on the matter they would be afraid to tell me honestly since the official word is: vaccine everybody with NO questions. So, I have lost trust in my physicians. a year ago I asked for HCQ to keep in my medicine cabinet, “just in case.” My physician said she could not prescribe because it was not “the standard of care.” I asked her what was and she said stay home until you get so bad you need hospitalization. Hmph. Great “standard of care.” I got it anyway from another source. I also have Ivermectin, which she won’t prescribe either. Gee, thanks, Doc. With the help of G0d I won’t need any of it but I sure worry less knowing I have SOMETHING in my arsenal that isn’t experimental and not potentially very harmful
But is ‘the small percent who become hospitalized from the disease’ higher than the percentage hospitalized from the vaccine? (hospitalization rate for Covid-19 in a 33-year-old is ~2.8%)? What about
Another question is – If I’m not immune and get infected, will I infect other people (maybe with immune problems)? Will I be a part in generating new variants?
If I was infected – are there any drawbacks to having a shot?
You have questions for the vaccine but not about the use of HCQ, Ivermectin etc.? What about the side effects of long-term use of Ivermectin (https://www.mayoclinic.org/drugs-supplements/ivermectin-oral-route/side-effects/drg-20064397)? This isn’t experimental?
What about Cov-SARS-2 (or use of HCQ/Ivermectin) ‘exacerbate some previous conditions’? Not woried?
David, there is no “long term” in the case of COVID treatment by either HCQ or Ivermectin.
It would only apply if it was used very long term as a Prophylactic.
I do have questions about ANY medication. Nobody is pushing HCQ and Ivermectin on me, but there is a suspicious amount of pressure, bribery, cajoling, and shaming for EVERYONE to take the jab indiscriminately with NO QUESTION. Just believe the people who keep getting it wrong. If I offered you a shot that I claim would prevent you from getting pregnant…BUT, but, but you still need to use birth control, what would you think? Would you bother with the jab that was only experimental and “approved” for emergency use? I am stunned that currently, there is NO pre-hospitalization treatment for early Covid. None. Yet, some doctors who immediately become de=platformed, fired, demeaned, and defunded claim to have success with some older and cheaper medications that appear to mitigate the progress of the disease. The toxicity and dosages are well-known in the case of HCQ and Ivermectin. Why is my doctor forbidden to prescribe those meds to me if I develop Covid? Forbidden!! And the pharmacies can’t fill the prescriptions? I smell a rat, and so should you. I am open to the jab WHEN I can find out if I don’t already have the natural antibodies or T-cells. I’m just having a problem taking anything from known eugenicists who openly support de-population. Much easier if the masses voluntarily sign up.
Well said. The suppression of Ivermectin and HCQ alone (the WHO initially referred to the Merck press release as proof that Ivermectin was dangerous – what a joke!) should make people suspicious of an agenda, *even if* one doesn’t think they are particularly effective. The precautionary principle says doctor’s should be allowed to prescribe them if they will do no harm and may help.
Then there’s the sheer lie being blasted globally that vaccines are the only way to attain herd immunity AND natural immunity mysteriously no longer works. You would have to be obtuse or under some sort of spell to not see how lacking in logic that is. I had a very intelligent friend (AI expert and engineer) tell me that vaccines were the only way to reach herd immunity, and only when I pointed out the logical fallacy did he realise his error. That is pure buy-in to the corporate media.
Thank you. Don’t forget that we are being asked to trust the integrity of eugenicists who support de-population. We will see if our youth have fertility problems in the future, youth who, in my humble opinion, have NO business getting the Covid jab.
First – hundreds of clinical trials have been run on Ivermectin and HCQ – Is that suppression?
Second – no pharmaceutical is benign. Any compound that has a biological activity can be both beneficial and harmfully. The question is ‘is the benefit larger that the harm’?
Third – ‘herd immunity’ is both vaccination AND infection. Vaccination is faster and more evenly spread. Infection spreads organically through a population, leaving large sections without any immunity. The same percentage of immune people provide more herd immunity if they are more evenly spread out (like a chess board) than all bunched together.
Why do you think that the virus is less dangerous than the vaccine? Will we have long term problems related to viral infections (https://www.goodrx.com/blog/can-covid-19-cause-autoimmune-diseases/, https://www.scientificamerican.com/article/a-tsunami-of-disability-is-coming-as-a-result-of-lsquo-long-covid-rsquo/, https://www.sciencemag.org/news/2020/07/brain-fog-heart-damage-covid-19-s-lingering-problems-alarm-scientists)?
I wanted to know what Sebastian’s take is. At what age would he recommend getting vaccinated?
The question asked was ‘Are the covid vaccines safe and effective’. I think I understand the answer to the first to be ‘highly effective’, as in yes.
What is the answer to the second? How will we know? What is ‘safe enough’? Having questions is great – we all have questions. But how do we get answers?
David, there is no “immunity” with these Vaccines, they don’t stop you getting COVID, they don’t stop you infecting others, they don’t stop you getting ill, only lower the odds and they don’t stop you dying of COVID either.
What was your question about immunity again?
How dangerous is Covid-19? That’s a good question. Why are the jabs being pushed on EVERYONE indiscriminately? That’s a huge red flag for me. We have documented (this won’t include those who had it unknowingly) 34,600,000 “cases.” We have documented 621,000 deaths (probably including “suspected” deaths or deaths WITH Covid not BY Covid). Thus to use the numbers, the case mortality rate is 1.8%, but likely much lower due to asymptomatic cases. The death rate for the USA (using 325, 000,000) is 0.19%. I AM worried about the possible short-term effects and the longer-term effects of the jab. I may wait until it is (1) approved and (2) a test is available to see if I already carry immunity. I don’t think this is irresponsible or crazy. I am merely in the control group of the experiment. Also, I had a bad “flu” at the end of February 2020. Was it flu or Covid? I’ll never know, apparently, but take the jab anyway, I’m told. Also, two people who worked in my house in August both came down with symptoms 2 days later and tested positive. I never got sick despite likely exposure. Another clue that either exposure doesn’t always = catching it and/or I already may be immune. Just clues. My other friend has had two jabs. Each time he immediately developed a mental condition that he literally didn’t know where he was for 24 hours. He reported it to his doctor who made it clear that he was not going to forward this adverse reaction anywhere.
what I dearly miss in this article is how any of these studies can be accurate since the PCR-test is the only tool used to ‘detect’ Covid and it is by now (and was then too) known that the PCR-test had such a low accuracy that these studies actually say nothing at all. If you have another view I am really interested in reading it.
And thank you for your latest article about drug trials
Excellent point! Also, I believe we should know how many cts the lab used before getting to a positive result. If negative at 35 cts but positive at 40, is it really Covid with no clinical symptoms and is it even contagious at that point?
Exactly! And the data is getting muddier by the moment. The CDC are apparently now recommending tests from vaccinated individuals be run at around 25-28 cycles (have seen reports mentioning both) and unvaccinated individuals at 40-45 cycles. Why this discrepancy? I can think of no rational scientific reason to do so. At least not if you’re looking for an accurate signal … instead of massively inflating unvaccinated ‘cases’ with false positives and people who don’t have the disease.
Labs won’t tell you how many cycles they completed to get to your positive rating. I asked my doc how many cts the lab they use were testing to and she replied, ” What is a cycle?” It is not even clear that if you are negative, let’s say, to 30, 35, 39 cycles then positive at 40, do you even have the clinical disease? Are you even contagious? A virologist told me that at those high numbers (anything over 20-25 cts) you’re looking at “viral poop” and not a disease.
Dr. Rushworth, I have a question.
In view of the 1000s of Deaths associated with Vaccines in both the USA & Europe plus the 100s of thousands of Adverse Events do you consider the Study Trials you reviewed to be worth the paper they were written on?
Now we also have the data from Israel that their Pfizer vaccine has zero efficacy for the Delta variant.
this blog is fantastic, and a great source of information, thank you sebastian!
i’m a 43 year old male living in the united kingdom. i work from home and only really leave the house to run, so i’ve managed to avoid getting covid-19, despite someone i live with getting it earlier this year. confirmed via antibody test. part of me wishes i had got it early on when there were no vaccines, as i would not have this vaccine dilemma now.
i am in the minority that is still unvaccinated. and i still can’t make up my mind what to do. i’m neither pro or anti vax, just very hesitant, especially with this one, and now i have decision fatigue.
i’m healthy, slim, fairly active (run 2.5k every day) no health conditions. all bloods are very good, vitamin d around 100 nmol/L achieved by taking 5000iu daily for the last eighteen months. i lose points for total cholesterol being 5 mmol/L, slightly raised bilirubin (gilbert’s) and slight alpha-1 deficiency but MS genotype, none of these are really issues.
to moderna or not to moderna?
I would love an update on the safety profiles of each of the major vaccines available, including the protein based Novavax.
I am in Victoria, Australia and it is now almost impossible to live without being covid vaccinated.
if I have to have take a vaccine, I would like to take the safest.
Roger: I would suggest steering clear of the mRNA gene-theragy jabs (Pfizer and Moderna), but, in truth, the safety profiles of all the U.S.-licensed jabs are horrendous. The injuries and deaths are being ignored, swept under the rug, and we will never know with any accuracy because the clinical trials have been abandoned. I highly recommend RFK, Jr.’s “The Real Anthony Fauci.” Enough to make any decent person take to the streets. Evil is in charge.
We are following your blog regularly. I find this post great, but since it is almost a year old I was wondering if and how your Attitude towards the different vaccines changed. What would you feel would be the go to vaccine now if you had to get vaccinated and do you feel that with more data now your concerns from a year ago are lessened?
All the Best
Agreed. This post needs updating including sorting through the court-mandated release of FDA documents which showed 17 deaths from all causes in the placebo arm of the Pfizer vaccine trial versus 21 deaths from all causes in the vaccine arm.
See page 23.
“From Dose 1 through the March 13, 2021 data cutoff date, there were a total of 38 deaths, 21 in the COMIRNATY group and 17 in the placebo group. None of the deaths were considered related to vaccination.”
None of the deaths were considered related to vaccination? How would the investigators know? What would doctors/coroners look for? Where is the guidance from any public health agencies about how to rule out vaccines as cause of death?
Were there any deaths after the cutoff date? How would we know? How would we compare if those in the placebo group were vaccinated?